BAD_binding partners*

Protein BAD_binding partners* map

Identifiers
BAD_binding partner*
B-cell CLL/lymphoma 2
HUGO:BCL2 HGNC:990 ENTREZ:596 UNIPROT:P10415 GENECARDS:BCL2 REACTOME:50758 KEGG:596 ATLASONC:BCL2ID49 WIKI:BCL2
BCL2-like 1
HUGO:BCL2L1 HGNC:992 ENTREZ:598 UNIPROT:Q07817 GENECARDS:BCL2L1 REACTOME:50772 KEGG:598 ATLASONC:BCL2L1ID129ch20q11 WIKI:BCL2L1

Maps_Modules
 EMT  map  / EMT_REGULATORS  map

References
PMID:22039431
The Bcl2 family proteins regulate and mediate the mitochondrial outer membrane permeabilization, a crucial event in the mitochondrial pathway of apoptosis in vertebrates.
The regulation of apoptosis is governed largely by interactions between the pro-survival and pro-death members of the Bcl2 protein family.
Some members of this family (e.g., Bax, Bak, and Bid: pro-apoptotic proteins) promote apoptosis, while others such as BCL2, BCL2L1, BCL2L2 (anti-apoptotic proteins) work against programmed cell death.
The BCL2 family proteins are characterized by regions of specific sequence homology named as BCL2 homology (BH) motifs that number from 1 to 4 and are critical for function.
Especially a helical BH3 motif of pro-apoptotic proteins occupy and form strong interactions with hydrophobic groove of anti-apoptotic BCL2 family proteins which leads to the activation of the essential death mediators Bax and Bak, thereby committing cells to apoptosis
PMID:23064052
BCL2 and BCL2L1 are known to be overexpressed in several cancers.
PMID:12175651
PMID:10826997
PMID:12767520
PMID:19030972
PMID:16931767
PMID:21540285
PMID:12444011
IGFfamily exhibits anti-apoptotic activity.
Three IGF1R-induced anti-apoptotic pathways:
1. IRS1-mediated pathway causing activation of PI3K and AKT(PKB) leading to BAD phosphorylation.
Unphosphorylated BAD, by binding to BCLXL and BCL2, neutralizes the protective effect of these 2 later proteins and promotes cell death.
Phosphorylated BAD is sequestered by 14-3-3 protein family and thus unable to bind BCL2 family hence can not promote cell death.
2. After autophosphorylation and thus activation, IGF1R binds to 14-3-3 protein family, leading to activation and translocation of c-Raf1 to the mitochondria where it phosphorylates BAD.
3. IGF1R specifically phosphorylates and inhibits ASK1 (MAP3K5)


Modifications:
In compartment: Mitochondria
  1. BAD_binding partners*@Mitochondria map

Participates in complexes:
In compartment: Mitochondria

  1. BAD:​BAD_binding partners*@Mitochondria map

Participates in reactions:
As Reactant or Product:

  1. BAD_binding partners*@Mitochondria map map BCL2@Mitochondria map

  2. BAD_binding partners*@Mitochondria map map BCL2-XL*@Mitochondria map
  3. BAD_binding partners*@Mitochondria map + BAD@Mitochondria map map BAD:​BAD_binding partners*@Mitochondria map
  4. BAD:​BAD_binding partners*@Mitochondria map map Apoptosis@Cytoplasm map

As Catalyser:

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