AXIN*:CK1_alpha_*:GSK3*:G_alpha_o*:_beta_-Arrestin2*

Complex AXIN*:CK1_alpha_*:GSK3*:G_alpha_o*:_beta_-Arrestin2* map


Complex composition:

  1. CK1_alpha_* map
  2. AXIN* map
  3. GSK3* map
  4. G_alpha_o* map
  5. _beta_-Arrestin2* map




AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Endosome

Identifiers
NAME:AXIN*:CK1_alpha_*:GSK3*:G_alpha_o*:_beta_-Arrestin2*

Maps_Modules
 Survival  map  / WNT_CANONICAL  map

References
PMID:21606194
s_wca1_re43( Survival  map ):
PMID:21606194 PMID:21285348
DVL is again phosphorylated to form PS-DVL. This isoform of DVL leads to depolimerisation of DVL and even distribution in the cell. Which CK1 isoform catalyses this reaction is unknown

Confidence
REF=2 FUNC=4

AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Cytoplasm

Identifiers
NAME:AXIN*:CK1_alpha_*:GSK3*:G_alpha_o*:_beta_-Arrestin2*

References
s_wca1_re45:( Survival  map ) PMID:20460648 PMID:18077588 PMID:19705439 PMID:17426148
s_wca1_re33( Survival  map ):
PMID:19561074 PMID:20460648 PMID:19581931 PMID:21304492 PMID:21498506
AMER1 recruits axin
s_wca1_re37( Survival  map ):
PMID:20229235 PMID:18077588 PMID:21304492 PMID:21498506
Phosphorylation of the repeat PPSP A allows recruitment of additional GSK/AXIN which phosphorylates LRP5/6 on other PPSP repeats resulting of sequestering of GSK3 and AXIN away from the destruction complex
AMER1 recruits axin and GSk3

Confidence
REF=5 FUNC=4


Modifications:
Participates in complexes:
In compartment: Cytoplasm
  1. AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Cytoplasm map

In compartment: Endosome

  1. AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Endosome map

Participates in reactions:
As Reactant or Product:

  1. AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae map + AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Cytoplasm map map AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map

  2. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map + AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Cytoplasm map map AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  3. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome map map AMER1*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho|​pho:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome map + AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Endosome map
  4. s_s_wca1_s1187 + AXIN*:​CK1_alpha_*:​GSK3*@Cytoplasm map + _beta_-Arrestin2*@Cytoplasm map map AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Cytoplasm map
  5. AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Endosome map map Recycling @Cytoplasm map
  6. AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Endosome map map Degradation@Cytoplasm map

As Catalyser:

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