aVb3*_aVb5*

Protein aVb3*_aVb5* map

Identifiers
aVb3*_aVb5*
NAME:aVb3*
ITGAV/ITGB3
integrin, alpha V
“antigen identified by monoclonal antibody L230″, “integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)”, MSK8, “vitronectin receptor”, VNRA, VTNR
HUGO:ITGAV HGNC:6150 ENTREZ:3685 UNIPROT:P06756 GENECARDS:ITGAV REACTOME:57593 KEGG:3685 ATLASONC:GC_ITGAV WIKI:ITGAV
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
GP3A
HUGO:ITGB3 HGNC:6156 ENTREZ:3690 UNIPROT:P05106 GENECARDS:ITGB3 REACTOME:57601 KEGG:3690 ATLASONC:GC_ITGB3 WIKI:ITGB3
NAME:aVb5*
ITGAV/ITGB5
integrin, beta 5
HUGO:ITGB5 HGNC:6160 ENTREZ:3693 UNIPROT:P18084 GENECARDS:ITGB5 REACTOME:57605 ATLASONC:GC_ITGB5 WIKI:ITGB5

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / ECM  map
 EMT  map  / CELL_MATRIX_ADHESIONS  map

aVb3*_aVb5*@Extracellular space

References
e_re913( EMT  map ):
PMID:19161977
In the endoplasmic reticulum, integrin subunits find their binding partners and form heterodimers.
Monomeric integrins never reach the cell surface.
Integrins a1b1, a2b1, a10b1 and a11b1 bind to collagens
PMID:12297042
Cell adhesion to components of the ECM is important in the angiogenesis
PMID:2153105
PMID:2786007
PMID:7639691
PMID:10809728
integrins are receptors for different ECM proteins: Collagen 1, 4; Laminin 1, 8; Fibronectin and Vitronectin
PMID:7522194
PMID:16195317
Interactions between integrins and the ECM proteins result in focal cell adhesion and cytoskeleton remodeling.


Modifications:
In compartment: Extracellular space
  1. aVb3*_aVb5*@Extracellular space map

Participates in complexes:
In compartment: Extracellular space

  1. Vitronectin*:​aVb3*_aVb5*@Extracellular space map

Participates in reactions:
As Reactant or Product:

  1. aVb3*_aVb5*@Extracellular space map + Vitronectin*@Extracellular space map map Vitronectin*:​aVb3*_aVb5*@Extracellular space map

  2. aVb3*_aVb5*@Extracellular space map map ITGAV:​ITGB3@Cytoplasm map
  3. aVb3*_aVb5*@Extracellular space map map ITGAV:​ITGB5@Cytoplasm map
  4. Vitronectin*:​aVb3*_aVb5*@Extracellular space map map Cell-matrix adhesions@Extracellular space map

As Catalyser:

  1. VAV1@Cytoplasm map map VAV1@Cytoplasm map

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