ATR:ATRIP:CHEK1:CLSPN:PCNA:TIM1*

Complex ATR:ATRIP:CHEK1:CLSPN:PCNA:TIM1* map


Complex composition:

  1. CHEK1 map
  2. ATR map
  3. TIM1* map
  4. ATRIP map
  5. PCNA map
  6. CLSPN map




ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​PCNA|​K164_ubi:​TIM1*@default

Identifiers
NAME:ATR:ATRIP:CHEK1:CLSPN:PCNA:TIM1*

Maps_Modules
 DNA repair  map  / S_PHASE_CHECKPOINT  map

References
Stalled replication forks induce PCNA mono-ubiquitylation and formation of the complex that activated TLS and arrests S-phase
PMID:19793801, PMID:17582221, PMID:19158510, PMID:18451105
d_re119( DNA repair  map ):
For inhibition of S-checkpoint by ATM:
PMID:15175241, PMID:12086603
For inhibition of S-checkpoint by HCLK2/FAAP24/ATR/FANKM complex:
PMID:19282663, PMID:19622404, PMID:18995830
For interaction between SNM1B and ATM to mediate S-phase checkpoint in response to ICL (intra-chromatide lesion):
PMID:18469862
Resected DNA is a triger for activating the S-phase checkpoint and moving from G1 to S to G2:
PMID:20051983, PMID:16805667
For inhibition of S to G2 propagation and activation of S-phase checkpoint by complex PCNA:CtIP:
PMID:19342888
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. O6-methylguanine adducts recognized by MutSalpha, MutLalpha and BER pathways performs the repair. ATR/ATRIP S phase arrest is activated:
PMID:16713580
For role of TIM1*/TIPIN in S-phase checkpoint, stalled replication forks stabilisation and DNA repair during S-phase:
PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221
For inhibition of S-phase by ATR/ATRIP/CHEK1/CLSPN/HCLK2* complex:
PMID:19793801, PMID:17384638
For ATR/ATRIP/CHEK1/Tim* S-phase checkpoint
PMID:15798197
Formation of the complex for crosslink-activation of S phase checkpoint. FA core complex activates the reaction to stop S-phase propagaton:
PMID:14988723, PMID:15136767
d_re180( DNA repair  map ):
Phosphorylated Rev1 is the activator and the modulator of the TLC pathway in response to DNA damage and by cell cycle regulation
PMID:17035102
Several TLS polymerases participate in Fanconi in combination with HR and NER
PoL iota bypasses T-T adducts and dA-N6_BPDE, but only with assistance of Polkappa or Pol zeta:
PMID:15189446, PMID:12466554 (major)
Depending on the DNA damage, different TLS polymerases will be activated:
PMID:19225445
REV1 interacts with many TLS polymerases:
PMID:14657033
Polyubiquitination of PCNA activates prone-free mechanisms of lesions by-pass
PMID:19217833, PMID:18157158,
For TLS PMID:19258535
d_re437( DNA repair  map ):

Confidence
REF=5 FUNC=5


Modifications:
Participates in complexes:
In compartment: default
  1. ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​PCNA|​K164_ubi:​TIM1*@default map

Participates in reactions:
As Reactant or Product:

  1. TIM1*@default map + CLSPN|​pho@default map + PCNA|​K164_ubi@default map + ATRIP:​ATR|​pho@default map + CHEK1|​pho|​active@Nucleus map map ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​PCNA|​K164_ubi:​TIM1*@default map

As Catalyser:

  1. S phase@default map map G2 phase@default map

  2. gDamaged_DNA*@Nucleus map map gRepaired_DNA*@Nucleus map
  3. No DNA replicarion@default map map DNA replicarion@default map

Leave a Reply