ATR:ATRIP

Complex ATR:ATRIP map


Complex composition:

  1. ATR map
  2. ATRIP map




ATRIP:​ATR|​pho@default

Identifiers
NAME:ATR:ATRIP

Maps_Modules
 DNA repair  map  / G2_M_CHECKPOINT  map

References
PMID:15743907
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. O6-methylguanine adducts recognized by MutSalpha, MutLalpha and BER pathways performs the repair:
PMID:16713580
d_re260( DNA repair  map ):
DNA with O6-methylguanine adducts, MutSalpha and MutLalpha activate ATR/ATRIP and BER pathways performs the repair:
PMID:16713580, PMID:18543256
Damaged DNA triggers ATR/ATRIP complex activation
d_re5( DNA repair  map ):
9-1-1 complex activates TDG glycosylase and activates BER:
PMID:17855402
d_re33:( DNA repair  map ) PMID:15485915
d_re120( DNA repair  map ):
By CycB*/CDC2*:
G2/M transition
PMID:16818604
For BRCA2 and FANCD2/FANCDI importance in the cytokinesis and localisation at the spindle and role in the propagation of mitosis:
PMID:15375219, PMID:19686080
CDC2 has to be phosphorylated fot inhibition of G2 to M propagation (called G2 checkpoint). FANCC activates CDC2 phosphorylation
PMID:15377654
Brca1 ubiquitinates CtIp and in complex they inhibit G2 to M propagation (G2 checkpoint)
PMID:16818604, PMID:15485915
BRCA1 and FANCJ in complex inhibit G2 to M propagation (called G2 checkpoint).
PMID:15242590
FANCM:FAAP24 complex activated G2 phase checpoint (G2 to M propagation inhibition):
PMID:18995830
BER and MMR interaction and G2/M arrest inresponce to o6-meG formation:
PMID:14614141
d_re463( DNA repair  map ):
Arrests cell cycle in S-phase in response to stalled replication fork or ds breaks in DNA:
PMID:15459660, PMID:17384638, PMID:19793801

Confidence
REF=5 FUNC=0


Modifications:
Participates in complexes:
In compartment: default
  1. ATRIP:​ATR|​pho@default map

Participates in reactions:
As Reactant or Product:

  1. ATR|​pho|​active@Nucleus map + ATRIP@default map map ATRIP:​ATR|​pho@default map

  2. TOPBP1@default map + ATRIP:​ATR|​pho@default map + CLSPN|​pho@default map + RAD17|​pho@default map map ATRIP:​ATR|​pho:​CLSPN|​pho:​RAD17|​pho:​TOPBP1@default map
  3. ATRIP:​ATR|​pho@default map + CLSPN|​pho@default map + RPA1:​RPA2:​RPA3@default map map ATRIP:​ATR|​pho:​CLSPN|​pho:​RPA1:​RPA2:​RPA3@default map
  4. HCLK2*@default map + CLSPN|​pho@default map + ATRIP:​ATR|​pho@default map + CHEK1|​pho|​active@default map map ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​HCLK2*@default map
  5. TIM1*@default map + CLSPN|​pho@default map + PCNA|​K164_ubi@default map + ATRIP:​ATR|​pho@default map + CHEK1|​pho|​active@Nucleus map map ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​PCNA|​K164_ubi:​TIM1*@default map

As Catalyser:

  1. G2 phase@default map map M phase@default map

  2. CHEK1@default map map CHEK1|​pho|​active@default map
  3. CLSPN@default map map CLSPN|​pho@default map
  4. gDeaminated_alkylated_mismatched_base*@Nucleus map map gBER_M-glyc_DNA_st2*@Nucleus map + Base@default map

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