ATR

Protein ATR map

Identifiers
ataxia telangiectasia and Rad3 related
HUGO:ATR HGNC:882 ENTREZ:545 UNIPROT:Q13535 GENECARDS:ATR REACTOME:405632 KEGG:545 ATLASONC:ATRID728ch3q23 WIKI:ATR

Maps_Modules
 DNA repair  map  / G1_S_CHECKPOINT  map
 DNA repair  map  / S_PHASE_CHECKPOINT  map
 DNA repair  map  / G2_M_CHECKPOINT  map
 Cell cycle  map  / APOPTOSIS_ENTRY  map
 Cell cycle  map  / E2F1  map

References
For S-phase checkpoint
PMID:11877377, PMID:15459660, PMID:17384638, PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104
HCLK2*/FANCM/FAAP24/active ATR complex inhibits S-phase
PMID:19282663, PMID:19622404
For ATR/ATRIP/CHEK1/Tim* S-phase checkpoint
PMID:15798197

ATR|​pho|​active@Nucleus

References
d_re37( DNA repair  map ):
PMID:16332722, PMID:15136767
ATR binds stalled fork and phosphorylates CHK1 that activates checkpoint, stops cell cycle
d_re33:( DNA repair  map ) PMID:15485915
d_re43:( DNA repair  map ) PMID:16731533
d_re49:( DNA repair  map ) PMID:19788416
d_re71( DNA repair  map ):
For inactivation of EXO1 by 53BP1-mediated phosphorylation:
PMID:18756267, PMID:15867354
ATM and ATR phosphorylate EXO1 and lead to EXO1 ubiquitination and degradation:
PMID:18048416, PMID:11438669, PMID:20019063
d_re90( DNA repair  map ):
PMID:9488723, PMID:19772495
PMID:17303408
d_re110( DNA repair  map ):
Phosphorylation by ATM and ATR at T847, S327
Phosphorylation at S327 by ATM and ATR are essential for shift from A_NHEJ to HR
Phosphorylation by CDC2(CDK1) in cell cycle dep manner to shift from C_NHEJ ot HR at: Ser 267
This phosphorylation allows resection that initiates HR and blocks binding of Ku70/Ku80 complex that initiates C_NHEJ.
PMID:19357644, PMID:15485915, PMID:19490890, PMID:18716619 (for CDK-dep phosph), PMID:20051983
BRCA1 and CtIP interactions make shift from A_NHEJ and C_NHEJ toward HR
Resected DNA in HR is a positive trigger for amplification of the HR pathway (positive loop):
PMID:20051983
Only when CDKs are fully active, this fully activates HR during S and G2 phases:
PMID:18511906, PMID:18716619
d_re132:( DNA repair  map ) PMID:19841479, PMID:19793861
d_re160( DNA repair  map ):
PMID:18931676
PMID:19686080
Link between cell cycle and activation of Fanconi pathway
d_re186( DNA repair  map ):
PMID:18931676, PMID:19686080
d_re187( DNA repair  map ):
NBS1 is required for FANCD2 phosphorylation and relocation into the FA core complex:
PMID:14988723
d_re199( DNA repair  map ):
HCLK2*/FANCM/FAAP24/active ATR complex inhibit S-phase:
PMID:19282663, PMID:19622404, PMID:18995830
d_re205( DNA repair  map ):
Phosphorylation of NBS1 by ATR in response to crosslink-activation of S phase checkpoint
PMID:15136767, PMID:14988723
d_re206( DNA repair  map ):
Phosphorylation of NBS1 bt ATR in responce to crosslink-activation of S phase checkpoint
PMID:15136767
Formation of the complex for crosslink-activation of S phase checkpoint. FA core complex activates the reaction to stop cell cycle propagation:
d_re235( DNA repair  map ):
ATR phosphorylates XPA and activates NER during S-phase in response to damaged DNA, but not during other cc phases:
PMID:16540648, PMID:19004803
d_re260( DNA repair  map ):
DNA with O6-methylguanine adducts, MutSalpha and MutLalpha activate ATR/ATRIP and BER pathways performs the repair:
PMID:16713580, PMID:18543256
Damaged DNA triggers ATR/ATRIP complex activation
d_re315:( DNA repair  map ) PMID:16885023, PMID:17303408
d_re408:( DNA repair  map ) PMID:9858600

ATR@default

References
d_re37( DNA repair  map ):
PMID:16332722, PMID:15136767
ATR binds stalled fork and phosphorylates CHK1 that activates checkpoint, stops cell cycle

ATR@Nucleus

References
c_re132( Cell cycle  map ):
PMID:15024084
ATM phosphorylates p53 in case of DNA double-strand breaks. ATR phosphorylates p53 in case of other types of DNA damages.
PMID:15140942
E2F1 stimulates ATM to phosphorylate p53 (and Chk2)
PMID:15140942, PMID:9843217, PMID:9733515, PMID:9733514
c_re142( Cell cycle  map ):
Phosphorylation by ATR at Ser-317 et Ser-345
PMID:15190204, PMID:10859163, PMID:11090622, PMID:11390642, PMID:15279789, PMID:12781359, PMID:15272308, PMID:12766152, PMID:16431910, PMID:10859164, PMID:16360315
c_re622( Cell cycle  map ):
Upon DNA damage, E2F is stabilized by ATM phosphorylation.
PMID:15838517, PMID:15140942
14-3-3 tau mediates E2F1 stabilization. 14-3-3 tau interacts with ATM-phosphorylated E2F1 during DNA damage and inhibits E2F1 ubiquitination. 14-3-3 tau is also required for expression and induction of E2F1 apoptotic targets, such as p73, Apaf-1, and caspases, during DNA damage.
PMID:15494392


Modifications:
In compartment: Nucleus
  1. ATR@Nucleus map

  2. ATR|​pho|​active@Nucleus map

In compartment: default

  1. ATR@default map

Participates in complexes:
In compartment: default

  1. ATRIP:​ATR|​pho@default map

  2. ATR|​pho:​FAAP24*:​FANCM:​HCLK2*@default map
  3. ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​HCLK2*@default map
  4. ATRIP:​ATR|​pho:​CLSPN|​pho:​RAD17|​pho:​TOPBP1@default map
  5. ATR|​pho:​FANCD2|​K561_ubi|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map
  6. ATRIP:​ATR|​pho:​CLSPN|​pho:​RPA1:​RPA2:​RPA3@default map
  7. ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​PCNA|​K164_ubi:​TIM1*@default map
  8. ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​RPA1:​RPA2:​RPA3:​TIM1*:​TIPIN@default map

Participates in reactions:
As Reactant or Product:

  1. HCLK2*@default map + FAAP24*@default map + FANCM@default map + ATR|​pho|​active@Nucleus map map ATR|​pho:​FAAP24*:​FANCM:​HCLK2*@default map

  2. FANCD2|​K561_ubi|​pho@default map + MRE11*:​NBS1*|​S343_pho:​RAD50@default map + ATR|​pho|​active@Nucleus map map ATR|​pho:​FANCD2|​K561_ubi|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map
  3. ATR|​pho|​active@Nucleus map + ATRIP@default map map ATRIP:​ATR|​pho@default map
  4. TOPBP1@default map + ATRIP:​ATR|​pho@default map + CLSPN|​pho@default map + RAD17|​pho@default map map ATRIP:​ATR|​pho:​CLSPN|​pho:​RAD17|​pho:​TOPBP1@default map
  5. ATR@default map map ATR|​pho|​active@Nucleus map
  6. ATRIP:​ATR|​pho@default map + CLSPN|​pho@default map + RPA1:​RPA2:​RPA3@default map map ATRIP:​ATR|​pho:​CLSPN|​pho:​RPA1:​RPA2:​RPA3@default map
  7. HCLK2*@default map + CLSPN|​pho@default map + ATRIP:​ATR|​pho@default map + CHEK1|​pho|​active@default map map ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​HCLK2*@default map
  8. TIM1*@default map + CLSPN|​pho@default map + PCNA|​K164_ubi@default map + ATRIP:​ATR|​pho@default map + CHEK1|​pho|​active@Nucleus map map ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​PCNA|​K164_ubi:​TIM1*@default map
  9. ATRIP:​ATR|​pho:​CLSPN|​pho:​RPA1:​RPA2:​RPA3@default map + TIPIN@default map + TIM1*@default map + CHEK1|​pho|​active@default map map ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​RPA1:​RPA2:​RPA3:​TIM1*:​TIPIN@default map

As Catalyser:

  1. p53*@Nucleus map map p53*|​Ser15_pho@Nucleus map

  2. CHEK1@Nucleus map map CHEK1|​S317_pho|​S345_pho@Nucleus map
  3. DP1*:​E2F1|​Lys_ace:​PCAF*@Nucleus map map DP1*:​E2F1|​Lys_ace|​Ser31_pho@Nucleus map + PCAF*@Nucleus map
  4. CTIP*|​emp@default map map CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho@default map
  5. S phase@default map map G2 phase@default map
  6. G2 phase@default map map M phase@default map
  7. SMARCAL1@default map map SMARCAL1|​pho@default map
  8. FANCI@default map map FANCI|​pho@default map
  9. gDamaged_DNA*@Nucleus map map gRepaired_DNA*@Nucleus map
  10. FANCA@default map map FANCA|​pho@default map
  11. FANCD2@default map map FANCD2|​pho@default map
  12. FANCG@Nucleus map map FANCG|​S7_pho@default map
  13. NBS1*@default map map NBS1*|​S343_pho@default map
  14. XPA@Nucleus map map XPA|​S196_pho@Nucleus map
  15. RAD17@default map map RAD17|​pho@default map
  16. CHEK1@default map map CHEK1|​pho|​active@default map
  17. ORC1*:​ORC2*:​ORC3*:​ORC4*:​ORC5*:​ORC6*@default map + MCM2:​MCM3:​MCM4:​MCM5:​MCM6:​MCM7@default map + CDT1@default map + CDC6@default map + CDC45@default map + POLA*@default map + PRIM*@default map + RPA1@Nucleus map + RPA2@Nucleus map + RPA3@Nucleus map map CDC45:​CDC6:​CDT1:​MCM2:​MCM3:​MCM4:​MCM5:​MCM6:​MCM7:​ORC1*:​ORC2*:​ORC3*:​ORC4*:​ORC5*:​ORC6*:​POLA*:​PRIM*:​RPA1:​RPA2:​RPA3@default map
  18. CTBP*@default map map CTBP*|​S181_pho|​T179_pho|​S185_pho@default map
  19. BRCA1@default map map BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho|​active@default map
  20. PARP1@Nucleus map map PARP1|​PolyADPribose_unk|​pho@Nucleus map
  21. RPA2@default map map RPA2|​pho@default map
  22. No DNA replicarion@default map map DNA replicarion@default map
  23. SMC1*@default map map SMC1*|​S957_pho|​S966_pho@default map
  24. SMC3@default map map SMC3|​S1083_pho@default map
  25. RAD1@default map + RAD9*|​pho@default map + HUS1@default map map HUS1:​RAD1:​RAD9*|​pho@default map
  26. HUS1:​RAD1:​RAD9*|​pho@default map + RAD17@default map + RFC*@Nucleus map map HUS1:​RAD1:​RAD17:​RAD9*:​RFC*@default map
  27. CLSPN@default map map CLSPN|​pho@default map
  28. MDM2@default map map MDM2|​pho@default map
  29. gDeaminated_alkylated_mismatched_base*@Nucleus map map gBER_M-glyc_DNA_st2*@Nucleus map + Base@default map
  30. SIAH*@default map map SIAH*|​pho@default map
  31. PARP2@default map map PARP2|​unk|​pho@default map
  32. EXO1@default map map EXO1|​S692_pho|​S372_pho|​S567_pho|​S587_pho@default map
  33. CHEK2@default map map CHEK2|​pho|​active@default map
  34. H2AFX@default map map H2AFX|​pho@default map

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