Protein ASK1*

Identifiers
mitogen-activated protein kinase kinase kinase 5
HUGO:MAP3K5 HGNC:6857 ENTREZ:4217 UNIPROT:Q99683 GENECARDS:MAP3K5 KEGG:4217 ATLASONC:GC_MAP3K5 WIKI:MAP3K5
MEKK5

Maps_Modules
 Apoptosis   / TNF_RESPONSE 
 Survival   / WNT_NON_CANONICAL 

References
synonym:ASK1

ASK1*@Cytoplasm

References
a_re1311( Apoptosis  ):
PMID:10411906
in Hela, overexpression of 14-3-3 isoform YWHAZ suppresses ASK1 overexpression-induced apoptosis
PMID:18292600
by PP2A
PMID:12813029
identification of DAB2IP as a negative regulator of ASK1:14-3-3 interaction
a_re1307:( Apoptosis  ) PMID:10688666
a_re1325( Apoptosis  ):
PMID:9774977
ASK1 activation by TRAF2 upon TNF
in vascular endothelial cell, by DAB2IP
PMID:15310755
DAB2IP

ASK1*|​unk|​S967_pho@Cytoplasm

References
a_re1309:( Apoptosis  ) PMID:10411906
a_re1311( Apoptosis  ):
PMID:10411906
in Hela, overexpression of 14-3-3 isoform YWHAZ suppresses ASK1 overexpression-induced apoptosis
PMID:18292600
by PP2A
PMID:12813029
identification of DAB2IP as a negative regulator of ASK1:14-3-3 interaction

ASK1*|​oligomer@Cytoplasm

References
a_re1324( Apoptosis  ):
PMID:11689443
in 293T, in Hela, in L929, interaction between ectopically expressed tagged ASK1 and PPP5
in Hela, PPP5 expression inhibits ASK1 activity
in vitro, purified ASK1 dephosphorylated by recombinant PPP5
a_re1325( Apoptosis  ):
PMID:9774977
ASK1 activation by TRAF2 upon TNF
PMID:18292600
in vascular endothelial cell, by DAB2IP
PMID:15310755
DAB2IP
a_re1308( Apoptosis  ):
PMID:11920685
no access to the article.
The abstract suggests that ASK1 activation could procede through autophosphorylation

ASK1*|​pho|​oligomer@Cytoplasm

References
a_re1308( Apoptosis  ):
PMID:11920685
no access to the article.
The abstract suggests that ASK1 activation could procede through autophosphorylation
a_re1324( Apoptosis  ):
PMID:11689443
in 293T, in Hela, in L929, interaction between ectopically expressed tagged ASK1 and PPP5
in Hela, PPP5 expression inhibits ASK1 activity
in vitro, purified ASK1 dephosphorylated by recombinant PPP5

ASK1*|​pho@Cytoplasm

References
s_wnc2_re77:( Survival  ) PMID:16648474

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Modifications:
In compartment: Cytoplasm

1. ASK1*@Cytoplasm

2. ASK1*|​pho@Cytoplasm
3. ASK1*|​oligomer@Cytoplasm
4. ASK1*|​pho|​oligomer@Cytoplasm
5. ASK1*|​unk|​S967_pho@Cytoplasm

Participates in complexes:
In compartment: Cytoplasm

1. ASK1*:​TXN@Cytoplasm

2. 14-3-3*|​unk:​ASK1*|​unk|​S967_pho@Cytoplasm

Participates in reactions:
As Reactant or Product:

1. TXN@Cytoplasm + ASK1*@Cytoplasm → ASK1*:​TXN@Cytoplasm

2. ASK1*|​oligomer@Cytoplasm → ASK1*|​pho|​oligomer@Cytoplasm
3. ASK1*@Cytoplasm → ASK1*|​unk|​S967_pho@Cytoplasm
4. ASK1*|​unk|​S967_pho@Cytoplasm + 14-3-3*|​unk@Cytoplasm → 14-3-3*|​unk:​ASK1*|​unk|​S967_pho@Cytoplasm
5. ASK1*|​unk|​S967_pho@Cytoplasm → ASK1*@Cytoplasm
6. ASK1*|​pho|​oligomer@Cytoplasm → ASK1*|​oligomer@Cytoplasm
7. ASK1*@Cytoplasm → ASK1*|​oligomer@Cytoplasm
8. ASK1*|​pho@Cytoplasm → ASK1*@Cytoplasm
9. ASK1*@Cytoplasm → p38*@Cytoplasm
10. ASK1*@Cytoplasm → JNK*@Cytoplasm

As Catalyser:

1. MAP2K4@Cytoplasm → MAP2K4|​pho@Cytoplasm

2. MAP2K3@Cytoplasm → MAP2K3|​pho@Cytoplasm
3. MAP2K6@Cytoplasm → MAP2K6|​pho@Cytoplasm