Artemis*:DNA-PK*:Ku70*:Ku80*:PARP3

Complex Artemis*:DNA-PK*:Ku70*:Ku80*:PARP3 map


Complex composition:

  1. Artemis* map
  2. Ku80* map
  3. Ku70* map
  4. DNA-PK* map
  5. PARP3 map




Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho:​DNA-PK*|​hm2:​Ku70*:​Ku80*:​PARP3@Nucleus

Identifiers
NAME:Artemis*:DNA-PK*:Ku70*:Ku80*:PARP3

Maps_Modules
 DNA repair  map  / C_NHEJ  map

References
The complex presents in double amount to cover both ends of broken DNA double helix
PMID:18558713
PARP3 and PARP1 in C_NHEJ
PMID:22469522, PMID:196269035
d_re95:( DNA repair  map ) PMID:11955432, PMID:19772495
d_re81( DNA repair  map ):
PoLL in C_NHEJ:
PMID:16738138
d_re105( DNA repair  map ):
PMID:18584027, PMID:17965729, PMID:20064462, PMID:18809224
For inhibition of A_NHEJ by DNA-PKs:
PMID:15211575
For stimulation of A_NHEJ by PARP1:
PMID:15498778, PMID:19362533, PMID:24050180
For role of MRN complex in A_NHEJ:
PMID:19654615, PMID:19892829
BLM inhibits A_NHEJ (alt_NHEJ):
PMID:24089143
PMID:24095737

Confidence
REF=5 FUNC=4


Modifications:
Participates in complexes:
In compartment: Nucleus
  1. Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho:​DNA-PK*|​hm2:​Ku70*:​Ku80*:​PARP3@Nucleus map

Participates in reactions:
As Reactant or Product:

  1. DNA-PK*|​hm2|​active@default map + Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho|​active@default map + Ku70*:​Ku80*@Nucleus map + PARP3@Nucleus map map Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho:​DNA-PK*|​hm2:​Ku70*:​Ku80*:​PARP3@Nucleus map

As Catalyser:

  1. gA_NHEJ_DNA_st1*@Nucleus map map gA_NHEJ_DNA_st2*@Nucleus map

  2. gC_NHEJ_DNA_st3*@Nucleus map map gC_NHEJ_DNA_st4*@Nucleus map

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