ARP2_3*

Protein ARP2_3* map

Identifiers
ARP2/3*
ARP2 actin-related protein 2 homolog (yeast)
“ARP2 (actin-related protein 2, yeast) homolog”
HUGO:ACTR2 HGNC:169 ENTREZ:10097 UNIPROT:P61160 GENECARDS:ACTR2 REACTOME:50299 KEGG:10097 ATLASONC:GC_ACTR2 WIKI:ACTR2
ARP3 actin-related protein 3 homolog (yeast)
“ARP3 (actin-related protein 3, yeast) homolog”
HUGO:ACTR3 HGNC:170 ENTREZ:10096 UNIPROT:P61158 GENECARDS:ACTR3 REACTOME:50303 KEGG:10096 ATLASONC:GC_ACTR3 WIKI:ACTR3

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CYTOSKELETON_POLARITY  map

ARP2_3*@Cytoplasm

References
e_re791( EMT  map ):
Rac1 binds to BAIAP2 which in turn associates with WASF2.
This stimulates ARP2/3 and leads to actin cytoskeleal polymerization.
PMID:16702231
WAVE2 (so-called WASF2) activates the ARP2/3 complex for Rac-induced actin polymerization during lamellipodium formation
PMID:9843499
WASF (WAVE) as regulator of actin reorganization downstream of Rac.
Expressed WAVE induces the formation of actin filament clusters.
WAVE plays a critical role downstream of Rac in regulating the actin cytoskeleton required for mem- brane ruffling
PMID:12054568
WAVE2 serves a functional partner of IRSp53 by regulating its interaction with Rac.
PMID:8625410
PMID:16293614
PMID:10467124
PMID:10511705
CDC42 induces actin cytoskeleton changes by activating WASP and N-WASP.
WASP and N-WASP binds to ARP2/3 and this lieads to actin cytoskeletal polymerization and filopodia formation.
PMID:14749719
PAK1 phosphorylates and activates ARP2_3 complex.
e_re798( EMT  map ):
PMID:15094799
ARP2_3 complex nucleates new actin filaments from the sides of preexisting filaments.


Modifications:
In compartment: Cytoplasm
  1. ARP2_3*@Cytoplasm map

Participates in complexes:
In compartment: Cytoplasm

  1. ARP2_3*:​Actin cytoskeletal*@Cytoplasm map

  2. ARP2_3*:​Actin cytoskeletal*:​Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​Vinculin*:​c-SRC*@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. ARP2_3*@Cytoplasm map map ACTR2@Cytoplasm map

  2. ARP2_3*@Cytoplasm map map ACTR3@Cytoplasm map
  3. ARP2_3*@Cytoplasm map map ARP2_3*@Cytoplasm map
  4. Actin cytoskeletal*@Cytoplasm map + ARP2_3*@Cytoplasm map map ARP2_3*:​Actin cytoskeletal*@Cytoplasm map
  5. ARP2_3*:​Actin cytoskeletal*@Cytoplasm map map Actin polymerization@Nucleus map
  6. ARP2_3*:​Actin cytoskeletal*@Cytoplasm map map Filopodium formation@Nucleus map
  7. ARP2_3*@Cytoplasm map + Actin cytoskeletal*:​Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​Vinculin*:​c-SRC*@Cytoplasm map map ARP2_3*:​Actin cytoskeletal*:​Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​Vinculin*:​c-SRC*@Cytoplasm map
  8. ARP2_3*:​Actin cytoskeletal*:​Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​Vinculin*:​c-SRC*@Cytoplasm map map Actin polymerization@Nucleus map

As Catalyser:

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