ARHGEF31*

Protein ARHGEF31* map

Identifiers
epithelial cell transforming sequence 2 oncogene
HUGO:ECT2 HGNC:3155 ENTREZ:1894 UNIPROT:Q9H8V3 GENECARDS:ECT2 REACTOME:195054 KEGG:1894 ATLASONC:ECT2ID40400ch3q26 WIKI:ECT2

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CYTOSKELETON_POLARITY  map

References
PMID:10579713
Human ECT2 (so-called ARHGEF31)is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis.
PMID:10837491
The level of GTP-Rho did not change significantly from the S phase to the prometaphase, but increased thereafter, peaking in the telophase, and returned to the original level in the G1 phase.
Expression of the dominant negative form of ECT2 completely suppressed both the rise of GTP-Rho in the telophase and the increased GDP-GTP exchange activity in the mitotic cell extracts.
These results suggest a critical role of ECT2 in Rho activation during cytokinesis

ARHGEF31*@Cytoplasm

References
e_re890( EMT  map ):
PMID:8836113
GEFs are essential for CDC42 activation. They promote the exchange of GDP to GTP to generate the activated form of CDC42 capable of recognizing downstram targets.
PMID:10579713
ARHGEF31 as a GEF of CDC42


Modifications:
In compartment: Cytoplasm
  1. ARHGEF31*@Cytoplasm map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. RhoA_GEFs*@Cytoplasm map map ARHGEF31*@Cytoplasm map

    2. Rac1_GEFs*@Cytoplasm map map ARHGEF31*@Cytoplasm map
    3. CDC42_GEFs*@Cytoplasm map map ARHGEF31*@Cytoplasm map

    As Catalyser:

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