GEF-H1(so-called ARHGEF2) is a microtubule-associated guanine nucleotide exchange factor that activates RhoA upon release from microtubules.
e_re730( EMT ):
GEF-H1 is so-called ARHGEF2
GEFH1, which associates with tubulin in a manner dependent on a Zn-finger motif, is a regulator of the Rho family
GEFH1 is known to activate Rho A, B, C, and Rac1 but is inactive toward Cdc42, TC10, or Ras.
GEFH1 may have a direct role in activation of Rac and/or Rho and in bringing the activated GTPase to specific target sites such as microtubules.
The activation of GEFH1- RhoB through the TRIF-dependent pathway of LPS in DC might be a critical target for controlling the activation of CD4+ T cells.
In compartment: Cytoplasm
Participates in complexes:
Participates in reactions:
As Reactant or Product:
- RhoA_GEFs*@Cytoplasm → ARHGEF2@Cytoplasm
- RhoB_GEFs*@Cytoplasm → ARHGEF2@Cytoplasm
- Rac1_GEFs*@Cytoplasm → ARHGEF2@Cytoplasm