ARHGEF2

Protein ARHGEF2 map

Identifiers
Rho/Rac guanine nucleotide exchange factor (GEF) 2
HUGO:ARHGEF2 HGNC:682 ENTREZ:9181 UNIPROT:Q92974 GENECARDS:ARHGEF2 REACTOME:195090 KEGG:9181 ATLASONC:ARHGEF2ID43150ch1q22 WIKI:ARHGEF2

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CYTOSKELETON_POLARITY  map

References
PMID:18287519
GEF-H1(so-called ARHGEF2) is a microtubule-associated guanine nucleotide exchange factor that activates RhoA upon release from microtubules.

ARHGEF2@Cytoplasm

References
e_re730( EMT  map ):
PMID:9857026
GEF-H1 is so-called ARHGEF2
GEFH1, which associates with tubulin in a manner dependent on a Zn-finger motif, is a regulator of the Rho family
GEFH1 is known to activate Rho A, B, C, and Rac1 but is inactive toward Cdc42, TC10, or Ras.
GEFH1 may have a direct role in activation of Rac and/or Rho and in bringing the activated GTPase to specific target sites such as microtubules.
PMID:16917499
The activation of GEFH1- RhoB through the TRIF-dependent pathway of LPS in DC might be a critical target for controlling the activation of CD4+ T cells.


Modifications:
In compartment: Cytoplasm
  1. ARHGEF2@Cytoplasm map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. RhoA_GEFs*@Cytoplasm map map ARHGEF2@Cytoplasm map

    2. RhoB_GEFs*@Cytoplasm map map ARHGEF2@Cytoplasm map
    3. Rac1_GEFs*@Cytoplasm map map ARHGEF2@Cytoplasm map

    As Catalyser:

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