ARHGEF14*

Protein ARHGEF14* map

Identifiers
MCF.2 cell line derived transforming sequence-like
HUGO:MCF2L HGNC:14576 ENTREZ:23263 UNIPROT:O15068 GENECARDS:MCF2L REACTOME:195027 KEGG:23263 ATLASONC:GC_MCF2L WIKI:MCF2L

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CYTOSKELETON_POLARITY  map

References
PMID:7957046
OST (so-called DBS, MCF2L, ARHGEF14) encodes a guanine nucleotide exchange factor that potentially links Rho and Rac signaling pathways
PMID:14701795
Co-expression of DBS with activated Rac1 causes enhanced focus forming activity and elevated levels of GTP�?RhoA in NIH3T3 cells
Interaction between activated Rac1 and DBS is specific for Rac1 and is not observed between Rac1 and several other members of the Rho-specific guanine nucleotide exchange factor family.
These results showed that activated Rac1 bt stimulation of DBS activity promotes RhoA activation.

ARHGEF14*@Cytoplasm

References
e_re767( EMT  map ):
PMID:14701795
Activated Rac1 activates ARHGEF14 which is a common activator for CDC2 and RHOA
Co-expression of Dbs with activated Rac1 causes enhanced focus forming activity and elevated levels of GTP-bound RhoA in NIH 3T3 cells, indicating that Dbs is activated by the interaction.


Modifications:
In compartment: Cytoplasm
  1. ARHGEF14*@Cytoplasm map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. RhoA_GEFs*@Cytoplasm map map ARHGEF14*@Cytoplasm map

    2. GTP:​RAC1@Cytoplasm map map ARHGEF14*@Cytoplasm map

    As Catalyser:

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