OST (so-called DBS, MCF2L, ARHGEF14) encodes a guanine nucleotide exchange factor that potentially links Rho and Rac signaling pathways
Co-expression of DBS with activated Rac1 causes enhanced focus forming activity and elevated levels of GTP�?RhoA in NIH3T3 cells
Interaction between activated Rac1 and DBS is specific for Rac1 and is not observed between Rac1 and several other members of the Rho-specific guanine nucleotide exchange factor family.
These results showed that activated Rac1 bt stimulation of DBS activity promotes RhoA activation.
e_re767( EMT ):
Activated Rac1 activates ARHGEF14 which is a common activator for CDC2 and RHOA
Co-expression of Dbs with activated Rac1 causes enhanced focus forming activity and elevated levels of GTP-bound RhoA in NIH 3T3 cells, indicating that Dbs is activated by the interaction.
In compartment: Cytoplasm
Participates in complexes:
Participates in reactions:
As Reactant or Product: