ARHGEF10L

Protein ARHGEF10L map

Identifiers
Rho guanine nucleotide exchange factor (GEF) 10-like
HUGO:ARHGEF10L HGNC:25540 ENTREZ:55160 UNIPROT:Q9HCE6 GENECARDS:ARHGEF10L KEGG:55160 ATLASONC:GC_ARHGEF10L WIKI:ARHGEF10L

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CYTOSKELETON_POLARITY  map

References
PMID:16112081
In vitro, GrinchGEF (ARHGEF10L) induced the GDP/ GTP exchange at RhoA, but not at Rac1 or Cdc42.
In intact cells, GrinchGEF induced specifically Rho activation and enhanced RhoA,B,C-specific downstream effect.
GrinchGEF, similar to its relative p164-RhoGEF (ARHGEF17), is a Rho-specific GEF.
Although RhoA, B, and C have different cellular functions, and some regulators and effectors show preferential interaction with these Rho isoforms, GrinchGEF apparently does not distinguish between RhoA,B,C and similarly activates these Rho proteins

ARHGEF10L@Cytoplasm

References
e_re732( EMT  map ):
PMID:16112081
In vitro, GrinchGEF (ARHGEF10L) induced the GDP/ GTP exchange at RhoA, but not at Rac1 or Cdc42.
In intact cells, GrinchGEF induced specifically Rho activation and enhanced RhoA,B,C-specific downstream effect.
GrinchGEF, similar to its relative p164-RhoGEF (ARHGEF17), is a Rho-specific GEF.
Although RhoA, B, and C have different cellular functions, and some regulators and effectors show preferential interaction with these Rho isoforms, GrinchGEF apparently does not distinguish between RhoA,B,C and similarly activates these Rho proteins


Modifications:
In compartment: Cytoplasm
  1. ARHGEF10L@Cytoplasm map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. RhoB_GEFs*@Cytoplasm map map ARHGEF10L@Cytoplasm map

    2. RhoA_GEFs*@Cytoplasm map map ARHGEF10L@Cytoplasm map

    As Catalyser:

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