ARHGDIG

Protein ARHGDIG map

Identifiers
Rho GDP dissociation inhibitor (GDI) gamma
HUGO:ARHGDIG HGNC:680 ENTREZ:398 UNIPROT:Q99819 GENECARDS:ARHGDIG REACTOME:195092 KEGG:398 WIKI:ARHGDIG

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CYTOSKELETON_POLARITY  map

References
PMID:9113980
RhoGDI (so-called ARHGDIA) and GDIG4 (so-called ARHGDIB) are two known GDIs for the Rho-subfamily of GTPases.
ARHGDIG is about 50 percent identical to ARHGDIA and ARHGDIB. ARHGFIG binds to CDC42 and RhoA with less affinity compared with ARHGDIA and does not bind with Rac1, Rac2, or Ras.
ARHGDIG functions as a GDI for CDC42 but with about 20 times less efficiency than ARHGDIA.

ARHGDIG@Cytoplasm

References
e_re683( EMT  map ):
PMID:9113980
RhoGDI (so-called ARHGDIA) and GDIG4 (so-called ARHGDIB) are two known GDIs for the Rho-subfamily of GTPases.
ARHGDIG is about 50 percent identical to ARHGDIA and ARHGDIB. ARHGFIG binds to CDC42 and RhoA with less affinity compared with ARHGDIA and does not bind with Rac1, Rac2, or Ras.
ARHGDIG functions as a GDI for CDC42 but with about 20 times less efficiency than ARHGDIA.
PMID:9490022
ARHGDIA,B,G are CDC42_GDIs
e_re729( EMT  map ):
The most known RhoB_GDIs are ARHGDIA and ARHGDIG.
They bind to RhoB and suppress its activation.
PMID:11368848
PMID:8939998
RhoGDI-3 (ARHGDIG) interacts specifically with GDP- and GTP-bound forms of post-translationally processed RhoB and RhoG proteins.
No interaction is found with RhoA, RhoC, or Rac1 proteins.
RhoGDI-3 is able to inhibit GDP/GTP exchange of RhoB and to release GDP-bound but not GTP-bound RhoB from cell membranes.


Modifications:
In compartment: Cytoplasm
  1. ARHGDIG@Cytoplasm map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. RhoA_and_CDC42_GDIs*@Cytoplasm map map ARHGDIG@Cytoplasm map

    2. RhoB_GDIs*@Cytoplasm map map ARHGDIG@Cytoplasm map

    As Catalyser:

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