ARHGAP35

Protein ARHGAP35 map

Identifiers
Rho GTPase activating protein 35
HUGO:ARHGAP35 HGNC:4591 ENTREZ:2909 UNIPROT:Q9NRY4 GENECARDS:ARHGAP35 REACTOME:195082 KEGG:2909 ATLASONC:GC_ARHGAP35 WIKI:ARHGAP35

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CYTOSKELETON_POLARITY  map

References
PMID:9819392
The GAP activity of ARHGAP35 (p190RhoGAP) is specific for RhoA inhibition.
PMID:8360177
RASA1 is a GAP for HRAS.
PMID:18829532
RasGAP actvity of RASA1 is reduced when associated with ARHGAP35 which is a specific GAP for RhoA
ARHGAP35 is tyrosine-phosphorylated.
The association of ARHGAP35 (p190) with RASA1 (p120) is promoted and stabilized by phosphorylation of p190 at Y1105 by PTK6..

ARHGAP35@Cytoplasm

References
e_re931( EMT  map ):
PMID:18829532
PMID:9819392
PTK6 and CSK both can phosphorylate ARHGAP35 (p190) at Y1105
RasGAP actvity of RASA1 is reduced when associated with ARHGAP35 which is a specific GAP for RhoA
ARHGAP35 is tyrosine-phosphorylated.
The association of ARHGAP35 (p190) with RASA1 (p120) is promoted and stabilized by phosphorylation of p190 at Y1105 by CSK or by PTK6.

ARHGAP35|​pho@Cytoplasm

References
e_re928( EMT  map ):
PMID:9819392
The GAP activity of ARHGAP35 (p190RhoGAP) is specific for RhoA inhibition.
e_re931( EMT  map ):
PMID:18829532
PTK6 and CSK both can phosphorylate ARHGAP35 (p190) at Y1105
RasGAP actvity of RASA1 is reduced when associated with ARHGAP35 which is a specific GAP for RhoA
ARHGAP35 is tyrosine-phosphorylated.
The association of ARHGAP35 (p190) with RASA1 (p120) is promoted and stabilized by phosphorylation of p190 at Y1105 by CSK or by PTK6.
e_re934( EMT  map ):
PMID:8360177
RASA1 is a GAP for HRAS.
The association of ARHGAP35 (p190) with RASA1 (p120) is promoted and stabilized by phosphorylation of p190 at Y1105 by PTK6..


Modifications:
In compartment: Cytoplasm
  1. ARHGAP35@Cytoplasm map

  2. ARHGAP35|​pho@Cytoplasm map

Participates in complexes:
In compartment: Cytoplasm

  1. ARHGAP35|​pho:​RASA1@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. RhoA_GAPs*@Cytoplasm map map ARHGAP35|​pho@Cytoplasm map

  2. ARHGAP35@Cytoplasm map map ARHGAP35|​pho@Cytoplasm map
  3. ARHGAP35|​pho@Cytoplasm map + RASA1@Cytoplasm map map ARHGAP35|​pho:​RASA1@Cytoplasm map

As Catalyser:

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