Apoptosis

Phenotype Apoptosis map
Apoptosis@Cytoplasm

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CYTOSKELETON_POLARITY  map
 EMT  map  / CELL_CELL_ADHESIONS  map
 EMT  map  / CELL_MATRIX_ADHESIONS  map
 EMT  map  / ECM  map
 EMT  map  / TIGHT_JUNCTIONS  map
 EMT  map  / GAP_JUNCTIONS  map
 EMT  map  / ADHERENS_JUNCTIONS  map
 EMT  map  / DESMOSOMES  map

References
PMID:22039431
Apoptosis or programmed cell death is a key regulatory process involved in major biological pathways in which its dysregulation is linked to cancer, autoimmunity, and neurodegenerative disorders
e_re428( EMT  map ):
PMID:11463392
BBC3 (so-called PUMA, p53 upregulated modulator of apoptosis) as a target for activation by p53.
This gene encodes two BH3 domain–containing proteins that are induced in cells following p53 activation.
BBC3 binds to BCL2, localize to the mitochondria to induce cytochrome c release, and activate the rapid induction of programmed cell death.
Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role inmediating p53-induced cell death through the cytochrome c/Apaf-1–dependent pathway.
PMID:11463391
PUMA was found to be exclusively mitochondrial and to bind to BCL2 and BCL2L1 through a BH3 domain.
PUMA Induces the Rapid Apoptosis of Colorectal Cancer Cells
It is via this binding to BBC3 (an apoptic inducer) that BCL2L1 exhibits its anti-apoptotic effect.
e_re435( EMT  map ):
PMID:14963330
Cytosolic localization of endogenous p53 was necessary and sufficient for apoptosis.
p53 directly activated the pro-apoptotic BCL2 protein Bax in the absence of other proteins to permeabilize mitochondria and engage the apoptotic program.
e_re1271( EMT  map ):
PMID:19153598
AKT1 blocks Apoptosis
e_re1614( EMT  map ):
PMID:12175651
PMID:10826997
PMID:12767520
PMID:19030972
PMID:16931767
PMID:21540285
PMID:12444011
IGFfamily exhibits anti-apoptotic activity.
Three IGF1R-induced anti-apoptotic pathways:
1. IRS1-mediated pathway causing activation of PI3K and AKT(PKB) leading to BAD phosphorylation.
Unphosphorylated BAD, by binding to BCLXL and BCL2, neutralizes the protective effect of these 2 later proteins and promotes cell death.
Phosphorylated BAD is sequestered by 14-3-3 protein family and thus unable to bind BCL2 family hence can not promote cell death.
2. After autophosphorylation and thus activation, IGF1R binds to 14-3-3 protein family, leading to activation and translocation of c-Raf1 to the mitochondria where it phosphorylates BAD.
3. IGF1R specifically phosphorylates and inhibits ASK1 (MAP3K5)

Apoptosis@Nucleus

References
s_shh2_re114:( Survival  map ) PMID:18379348

Apoptosis@Mitochondria

References
s_wnc2_re80:( Survival  map ) PMID:16648474

Apoptosis@Nucleus

References
s_wnc4_re10:( Survival  map ) PMID:15526030


Modifications:
In compartment: Cytoplasm
  1. Apoptosis@Cytoplasm map

In compartment: Mitochondria

  1. Apoptosis@Mitochondria map

  2. Apoptosis@Mitochondria map

In compartment: Nucleus

  1. Apoptosis@Nucleus map

  2. Apoptosis@Nucleus map
  3. Apoptosis@Nucleus map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. AKT1@Cytoplasm map map Apoptosis@Cytoplasm map

    2. BAD:​BAD_binding partners*@Mitochondria map map Apoptosis@Cytoplasm map
    3. MAP3K5@Cytoplasm map map Apoptosis@Cytoplasm map
    4. BBC3@Mitochondria map map Apoptosis@Cytoplasm map
    5. BAX:​p53*@Cytoplasm map map Apoptosis@Cytoplasm map
    6. BAK1:​p53*@Mitochondria map map Apoptosis@Cytoplasm map
    7. EMT@Cytoplasm map map Apoptosis@Cytoplasm map
    8. s_s_akt1_s533 map Apoptosis@Mitochondria map
    9. Caspase9__sub_TRUNC_endsub_*@Cytoplasm map map Apoptosis@Mitochondria map
    10. Caspase3*@Cytoplasm map map Apoptosis@Mitochondria map
    11. BAD@Mitochondria map map Apoptosis@Cytoplasm map
    12. Caspase3_sub_TRUNC_endsub_*@Cytoplasm map map Apoptosis@Cytoplasm map
    13. p53*|​pho@Nucleus map map Apoptosis@Cytoplasm map
    14. FOXO3|​pho@Nucleus map map Apoptosis@Cytoplasm map
    15. rFUS@Nucleus map map Apoptosis@Nucleus map
    16. Trail pathway@Nucleus map map Apoptosis@Nucleus map
    17. HIPK2@Nucleus map map Apoptosis@Nucleus map
    18. G_alpha__sub_13q_endsub_*:​PAR1_sub_TRUNC_endsub_*@Cytoplasm map map Apoptosis@Cytoplasm map
    19. MOMP@Mitochondria map map Apoptosis@Mitochondria map
    20. p38*@Cytoplasm map map Apoptosis@Mitochondria map
    21. JNK*@Cytoplasm map map Apoptosis@Mitochondria map
    22. AXIN*:​HIPK2:​p53*|​S46_pho@Nucleus map map Apoptosis@Nucleus map
    23. Caspase8_sub_TRUNC_endsub_*@Cytoplasm map map Apoptosis@Cytoplasm map
    24. Apoptosis@Cytoplasm map map Caspase3_sub_TRUNC_endsub_*@Cytoplasm map
    25. APC_sub_TRUNC_endsub_*@Mitochondria map map Apoptosis@Cytoplasm map

    As Catalyser:

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