APE*

Protein APE* map

Identifiers
APEX nuclease (multifunctional DNA repair enzyme) 1
HUGO:APEX1 HGNC:587 ENTREZ:328 UNIPROT:P27695 GENECARDS:APEX1 REACTOME:50120 KEGG:328 ATLASONC:GC_APEX1 WIKI:APEX1
APEX nuclease (apurinic/apyrimidinic endonuclease) 2
HUGO:APEX2 HGNC:17889 ENTREZ:27301 UNIPROT:Q9UBZ4 GENECARDS:APEX2 KEGG:27301 ATLASONC:GC_APEX2 WIKI:APEX2

Maps_Modules
 DNA repair  map  / BER  map

References
Apyrimidinic endonucleases, APE
PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013, PMID:20056333, PMID:11585362
For Phosphorylation by CK2
PMID:20955519, PMID:9407949
Inhibitors for APE in combination with oxidative stress to block BER and cause cancer cell death
PMID:23110144, PMID:22455312
CDK5 and MDM2 activate APE for shift to BER activity
PMID:21727086, PMID:21922195

APE*|​Thr233_pho|​ubi@default

References
d_re554:( DNA repair  map ) PMID:21727086, PMID:21922195, PMID:20724832
d_re2:( DNA repair  map ) deoxyribose-phosphatase activity of PolB
d_re8( DNA repair  map ):
GADD45 modulated and causes complex formation APE:PCNA. GADD is rgulated by p53:
PMID:17599061, PMID:23485469
d_re492( DNA repair  map ):
PMID:20955519
PMID:9407949

APE*|​pho@default

References
d_re492( DNA repair  map ):
PMID:20955519
PMID:9407949

APE*@default

References
d_re554:( DNA repair  map ) PMID:21727086, PMID:21922195, PMID:20724832


Modifications:
In compartment: default
  1. APE*@default map

  2. APE*|​pho@default map
  3. APE*|​Thr233_pho|​ubi@default map

Participates in complexes:
In compartment: default

  1. APE*|​Thr233_pho|​ubi:​Mg2+:​PCNA:​WRN@default map

Participates in reactions:
As Reactant or Product:

  1. APE*|​Thr233_pho|​ubi@default map map APE*|​pho@default map

  2. APE*@default map map APE*|​Thr233_pho|​ubi@default map
  3. Mg2+@default map + APE*|​Thr233_pho|​ubi@default map + PCNA@default map + WRN@Nucleus map map APE*|​Thr233_pho|​ubi:​Mg2+:​PCNA:​WRN@default map

As Catalyser:

  1. gBER_M-glyc_DNA_st2*@Nucleus map map gBER_M-glyc_DNA_st3*@Nucleus map

  2. gBER_M-glyc_DNA_st3*@Nucleus map map gShP_BER_M-glyc_st4_B-glyc_DNA_st4*@Nucleus map + 5′dRP@default map
  3. gShP_BER_M-glyc_st4_B-glyc_DNA_st4*@Nucleus map + dNTPs@Nucleus map map gShP_BER_M-glyc_st5_B-glyc_DNA_st5*@Nucleus map
  4. gBER_B-glyc_DNA_st3*@Nucleus map map gShP_BER_M-glyc_st4_B-glyc_DNA_st4*@Nucleus map + 3′ddR5P@default map

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