APC2*:CK1_epsilon_*:CTHRC1:DVL*:FZD*:GSK3*:PAR6*:RACK1*:ROR2:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*

Complex APC2*:CK1_epsilon_*:CTHRC1:DVL*:FZD*:GSK3*:PAR6*:RACK1*:ROR2:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2* map


Complex composition:

  1. DVL* map
  2. FZD* map
  3. ROR2 map
  4. WNT* map
  5. CK1_epsilon_* map
  6. APC2* map
  7. GSK3* map
  8. CTHRC1 map
  9. SYN4* map
  10. _beta_-Arrestin2* map
  11. VANGL* map
  12. RACK1* map
  13. PAR6* map
  14. RSPO3 map




APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome

Identifiers
NAME:APC2*:CK1_epsilon_*:CTHRC1:DVL*:FZD*:GSK3*:PAR6*:RACK1*:ROR2:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*

References
PCP MODULE
s_wnc1_re109( Survival  map ):
Polymerised Dvl act as scaffold for recruiting axin.
PMID:21078818
GSK3 phosphorylates ROR2
PMID:17986005
s_wnc1_re69( Survival  map ):
PMID:21069266
PMID:15388793
s_wnc1_re76( Survival  map ):
PMID:15375164
s_s_wnc1_re76( Survival  map ):

Confidence
REF=5 FUNC=3

APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome

Identifiers
NAME:APC2*:CK1_epsilon_*:CTHRC1:DVL*:FZD*:GSK3*:PAR6*:RACK1*:ROR2:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*

References
PCP MODULE
s_wnc1_re76( Survival  map ):
PMID:21078818
PMID:15375164
s_wnc1_re77( Survival  map ):
CK1 delta phosphorylates residues in cluster I: S84, S82, S79, T71 and in cluster II: S5, S8, S11, S14, S17, S20. Note: Experiments were performed in Xenopus
PMID:21316585

Confidence
REF=3 FUNC=3

APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WNT*:​_beta_-Arrestin2*@Endosome

Identifiers
NAME:APC2*:CK1_epsilon_*:CTHRC1:DVL*:FZD*:GSK3*:PAR6*:RACK1*:ROR2:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*

References
PCP MODULE
s_wnc1_re77( Survival  map ):
CK1 delta phosphorylates residues in cluster I: S84, S82, S79, T71 and in cluster II: S5, S8, S11, S14, S17, S20. Note: Experiments were performed in Xenopus
PMID:21316585
s_wnc1_re140( Survival  map ):
PMID:11779461
PMID:18256687

Confidence
REF=3 FUNC=3


Modifications:
Participates in complexes:
In compartment: Endosome
  1. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map

  2. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  3. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WNT*:​_beta_-Arrestin2*@Endosome map

Participates in reactions:
As Reactant or Product:

  1. APC2*:​GSK3*@Cytoplasm map + CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map map APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map

  2. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WNT*:​_beta_-Arrestin2*@Endosome map + WGEF*@Cytoplasm map + DAAM1@Cytoplasm map + RHOA@Cytoplasm map map APC2*:​CK1_epsilon_*:​CTHRC1:​DAAM1:​DVL*|​pho|​pho|​pho:​GSK3*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WGEF*:​_beta_-Arrestin2*@Cytoplasm map
  3. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map map WNT canonical pathway@Cytoplasm map
  4. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map map APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  5. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map map APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WNT*:​_beta_-Arrestin2*@Endosome map

As Catalyser:

  1. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map map APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map

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