APC

Protein APC map

Identifiers
adenomatous polyposis coli
HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC
“adenomatosis polyposis coli”

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CELL_CELL_ADHESIONS  map
 EMT  map  / ADHERENS_JUNCTIONS  map
 Survival  map  / WNT_CANONICAL  map
 Survival  map  / WNT_NON_CANONICAL  map

References
PMID:19751508
PMID:22270359
PMID:16940750
in the absence of Wnt ligands, b-catenin is phosphorylated by CK1 and GSK-3 in the context of a destruction complex with APC and Axin.
Phosphorylated b-catenin is consequently targeted for ubiquitination and degraded.
Upon ligand binding (right panel), DVL1 (dishevelled) recruits the Axin-GSK-3 complex, resulting in the sequential phosphorylation of LRP6 by CK1 and GSK-3.
Phoshorylated LRP6 serves as a docking site for additional Axin-GSK-3 complex, resulting in the disassembly of the destruction complex.
Non phosphorylated and thus stabilized b-catenin translocates to the nucleus where it activates transcription of target genes together with LEF/TCFs
PMID:20006983

APC@Cytoplasm

References
e_re1011( EMT  map ):
PMID:10581160
PMID:17318175
PMID:10421629
Recruitment of CTNNB1 via the degradation complex of APC/AXIN1 is regulated by a series of ordered phosphorylation events.
Phosphorylation of AXIN1 by CSNK1 (casein kinase 1) and GSK3B can increase axin binding to CTNNB1.
PMID:8638126
PMID:11487578
PMID:15327768
AXIN1 also promotes phosphorylation of APC by CSNK1 and GSK3B.
Phosphorylated APC has higher affinity to CTNNB1.
PMID:12554650
Finally, these phosphorylation events allo CTNNB1 to be a more efficient substrate of both CSNK1 (at S45) and the GSK3B (at T41, S33, S37).
The affinity of phosphorylated APC to CTNNB1 is higher than that of phosphorylated AXIN1.
Therefore upon phosphorylation, APC can displace AXIN1 from CTNNB1, allowing AXIN1 to bind another molecule of CTNNB1.

APC|​K63_ubi@Cytoplasm

Maps_Modules
 Survival  map  / WNT_CANONICAL  map

References
s_wca2_re64( Survival  map ):
HECTD1 KO disrupts APC-AXIN interaction and augments WNT3a-induced signaling
PMID:23277359 PMID:22761442
s_wca2_re65( Survival  map ):
Ubiquitination increases binding of APC with AXIN.
PMID:23277359

APC|​S2034_pho@Cytoplasm

References
s_wca3_re78( Survival  map ):
Site is adjacent to the NLS2 in APC
PMID:11689703
s_wca3_re85:( Survival  map ) PMID:10984057
s_wca3_re91:( Survival  map ) PMID:11585828

APC|​S2034_pho@Nucleus

References
s_wca3_re93:( Survival  map ) Not known if this dissociation occurs (here or later)
s_wca3_re85:( Survival  map ) PMID:10984057
s_wca3_re88:( Survival  map ) PMID:10984057 PMID:11263497

APC|​S2054_pho@Cytoplasm

References
s_wca3_re80:( Survival  map ) PMID:11689703

APC@Nucleus

References
s_wca3_re94:( Survival  map ) Not known if this dissociation occurs (here or later)
s_wca3_re81:( Survival  map ) PMID:18744248
s_wca3_re84:( Survival  map ) PMID:10984057
s_wca3_re89:( Survival  map ) PMID:10984057 PMID:11263497
s_wca3_re95:( Survival  map ) PMID:22787431
s_wca3_re104:( Survival  map ) PMID:15525529

APC|​pho@Cytoplasm

References
s_wnc4_re34( Survival  map ):
Unknown which amino acid residue
PMID:22399895


Modifications:
In compartment: Cytoplasm
  1. APC@Cytoplasm map

  2. APC|​pho@Cytoplasm map
  3. APC|​K63_ubi@Cytoplasm map
  4. APC|​S2034_pho@Cytoplasm map
  5. APC|​S2054_pho@Cytoplasm map

In compartment: Nucleus

  1. APC@Nucleus map

  2. APC|​S2034_pho@Nucleus map

Participates in complexes:
In compartment: Cytoplasm

  1. APC:​AXIN1@Cytoplasm map

  2. APC|​S2034_pho:​B56_alpha_*@Cytoplasm map
  3. (APC|​pho:​AXIN1|​pho)|​active@Cytoplasm map
  4. APC|​T1487_pho:​_beta_-Catenin*|​K345_ace|​ace@Cytoplasm map
  5. APC|​S1505_pho|​S1501_ubi|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_ubi:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho@Cytoplasm map
  6. APC|​pho:​AXIN1|​pho:​_beta_-Catenin*@Cytoplasm map
  7. APC|​pho:​AXIN1|​pho:​_beta_-Catenin*|​pho@Cytoplasm map
  8. APC|​pho:​AXIN1|​pho:​_beta_-Catenin*|​pho|​pho|​pho|​pho@Cytoplasm map
  9. APC|​K63_ubi:​AXIN*:​CK1_alpha_*:​GSK3*@Cytoplasm map
  10. AMER1*:​APC|​S1505_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map
  11. AMER1*:​APC|​S1505_pho|​S1501_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map
  12. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map
  13. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map
  14. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map
  15. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​E1*:​FAF*:​GSK3*:​NEDD8:​PKD*:​PtdIns(4,5)-P2:​RAD6*:​SKP*:​USP15:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho|​K19_ubi|​K49_ubi@Cytoplasm map

In compartment: Endosome

  1. AMER1*:​APC:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map

In compartment: Nucleus

  1. APC:​B56_alpha_*@Nucleus map

  2. APC:​CTBP*|​hm2@Nucleus map
  3. APC|​S2034_pho:​B56_alpha_*@Nucleus map
  4. APC|​T1487_pho:​_beta_-Catenin*|​K345_ace|​ace@Nucleus map
  5. APC:​CTBP*|​hm2:​HDAC1_2*@Nucleus map
  6. APC|​T1487_pho:​CTBP*|​hm2:​HDAC1_2*@Nucleus map
  7. APC|​T1487_pho:​BCL9:​CTBP*|​hm2:​DVL*:​HDAC1_2*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map

Participates in reactions:
As Reactant or Product:

  1. AXIN1@Cytoplasm map + APC@Cytoplasm map map APC:​AXIN1@Cytoplasm map

  2. APC:​AXIN1@Cytoplasm map map (APC|​pho:​AXIN1|​pho)|​active@Cytoplasm map
  3. (APC|​pho:​AXIN1|​pho)|​active@Cytoplasm map map APC:​AXIN1@Cytoplasm map
  4. _beta_-Catenin*@Cytoplasm map + (APC|​pho:​AXIN1|​pho)|​active@Cytoplasm map map APC|​pho:​AXIN1|​pho:​_beta_-Catenin*@Cytoplasm map
  5. Plakoglobin binding partners*@Cytoplasm map map APC@Cytoplasm map
  6. APC|​pho:​AXIN1|​pho:​_beta_-Catenin*|​pho@Cytoplasm map map APC|​pho:​AXIN1|​pho:​_beta_-Catenin*|​pho|​pho|​pho|​pho@Cytoplasm map
  7. APC|​pho:​AXIN1|​pho:​_beta_-Catenin*|​pho|​pho|​pho|​pho@Cytoplasm map map degraded
  8. APC|​pho:​AXIN1|​pho:​_beta_-Catenin*@Cytoplasm map map APC|​pho:​AXIN1|​pho:​_beta_-Catenin*|​pho@Cytoplasm map
  9. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map map AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map
  10. AXIN*:​CK1_alpha_*:​GSK3*@Cytoplasm map + APC@Cytoplasm map + AMER1*@Cytoplasm map map AMER1*:​AXIN*:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2@Cytoplasm map
  11. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map map AMER1*:​APC:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  12. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map + E1*:​FAF*:​NEDD8:​RAD6*:​SKP*@Cytoplasm map + CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​PKD*:​USP15@Cytoplasm map map AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​E1*:​FAF*:​GSK3*:​NEDD8:​PKD*:​PtdIns(4,5)-P2:​RAD6*:​SKP*:​USP15:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho|​K19_ubi|​K49_ubi@Cytoplasm map
  13. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​E1*:​FAF*:​GSK3*:​NEDD8:​PKD*:​PtdIns(4,5)-P2:​RAD6*:​SKP*:​USP15:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho|​K19_ubi|​K49_ubi@Cytoplasm map map CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​NEDD8:​PKD*:​RAD6*:​SKP*:​USP15@Cytoplasm map + APC|​S1505_pho|​S1501_ubi|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_ubi:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho@Cytoplasm map + _beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho|​K19_ubi|​K49_ubi@Cytoplasm map
  14. AMER1*:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map map AMER1*:​APC|​S1505_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map
  15. AMER1*:​APC|​S1505_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map map AMER1*:​APC|​S1505_pho|​S1501_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map
  16. s_s_wca1_s1651 map APC@Cytoplasm map + Microtubules@Cytoplasm map
  17. AMER1*:​APC|​S1505_pho|​S1501_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map map AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map
  18. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map map AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map
  19. APC@Cytoplasm map map APC|​K63_ubi@Cytoplasm map
  20. APC|​K63_ubi@Cytoplasm map + AXIN*:​CK1_alpha_*:​GSK3*@Cytoplasm map map APC|​K63_ubi:​AXIN*:​CK1_alpha_*:​GSK3*@Cytoplasm map
  21. APC|​K63_ubi:​AXIN*:​CK1_alpha_*:​GSK3*@Cytoplasm map map WNT canonical pathway@Cytoplasm map
  22. APC@Nucleus map + CTBP*|​hm2@Nucleus map map APC:​CTBP*|​hm2@Nucleus map
  23. HDAC1_2*@Nucleus map + APC:​CTBP*|​hm2@Nucleus map map APC:​CTBP*|​hm2:​HDAC1_2*@Nucleus map
  24. APC:​CTBP*|​hm2:​HDAC1_2*@Nucleus map map APC|​T1487_pho:​CTBP*|​hm2:​HDAC1_2*@Nucleus map
  25. APC|​T1487_pho:​CTBP*|​hm2:​HDAC1_2*@Nucleus map + BCL9:​DVL*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map map APC|​T1487_pho:​BCL9:​CTBP*|​hm2:​DVL*:​HDAC1_2*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map
  26. APC|​T1487_pho:​BCL9:​CTBP*|​hm2:​DVL*:​HDAC1_2*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map map APC|​T1487_pho:​_beta_-Catenin*|​K345_ace|​ace@Nucleus map + CTBP*:​p300*@Nucleus map + CTBP*:​HDAC1_2*:​LEF_TCF*:​WRE*@Nucleus map + DVL*:​JUN|​pho|​pho@Nucleus map
  27. APC|​T1487_pho:​_beta_-Catenin*|​K345_ace|​ace@Nucleus map map APC|​T1487_pho:​_beta_-Catenin*|​K345_ace|​ace@Cytoplasm map
  28. APC|​T1487_pho:​_beta_-Catenin*|​K345_ace|​ace@Cytoplasm map map Degradation complex WNT canoncical pathway@Cytoplasm map
  29. APC@Cytoplasm map + s_s_s4327 map s_s_wca3_s788
  30. APC@Cytoplasm map map s_s_s4327
  31. APC@Cytoplasm map map APC|​S2034_pho@Cytoplasm map
  32. APC|​S2034_pho:​B56_alpha_*@Cytoplasm map map APC|​S2034_pho:​B56_alpha_*@Nucleus map
  33. APC@Cytoplasm map map APC|​S2054_pho@Cytoplasm map
  34. APC@Nucleus map map DNA replication@Nucleus map
  35. s_s_wca3_s328 map APC:​B56_alpha_*@Nucleus map
  36. APC@Nucleus map map APC@Cytoplasm map
  37. APC|​S2034_pho@Nucleus map map APC|​S2034_pho@Cytoplasm map
  38. _beta_-Catenin*@Nucleus map + APC|​S2034_pho@Nucleus map map s_s_wca3_s314
  39. _beta_-Catenin*@Nucleus map + APC@Nucleus map map s_s_wca3_s317
  40. APC@Cytoplasm map + B56_alpha_*@Cytoplasm map map s_s_wca3_s328
  41. APC|​S2034_pho@Cytoplasm map + B56_alpha_*@Cytoplasm map map APC|​S2034_pho:​B56_alpha_*@Cytoplasm map
  42. APC|​S2034_pho:​B56_alpha_*@Nucleus map map B56_alpha_*@Nucleus map + APC|​S2034_pho@Nucleus map
  43. APC:​B56_alpha_*@Nucleus map map APC@Nucleus map + B56_alpha_*@Nucleus map
  44. APC@Nucleus map map BER DNA Repair@Nucleus map
  45. APC@Cytoplasm map map APC|​pho@Cytoplasm map
  46. AMER2:​PtdIns-(4,5)-P_sub_2@Cytoplasm map + EB1*@Cytoplasm map + APC@Cytoplasm map map AMER2:​EB1*:​PtdIns-(4,5)-P_sub_2@Cytoplasm map
  47. APC@Cytoplasm map map APC_sub_TRUNC_endsub_*@Cytoplasm map
  48. APC@Cytoplasm map + HTID1_50_48_kDa_isoform*@Cytoplasm map + HSP70*@Cytoplasm map + DVL*@Cytoplasm map + Actin cytoskeletal*@Cytoplasm map + AXIN*@Cytoplasm map + HSC70*@Cytoplasm map map AXIN*:​DVL*:​HSC70*:​HTID1_50_48_kDa_isoform*@Cytoplasm map

As Catalyser:

  1. AMER1*:​APC:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map map AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map

  2. Caspase8*@Cytoplasm map map Caspase8_sub_TRUNC_endsub_*@Cytoplasm map

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