APBB1

Protein APBB1 map

Identifiers
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
HUGO:APBB1 HGNC:581 ENTREZ:322 UNIPROT:O00213 GENECARDS:APBB1 KEGG:322 ATLASONC:GC_APBB1 WIKI:APBB1

Maps_Modules
 Apoptosis  map  / MITOCH_METABOLISM  map

References
synonym:FE65

APBB1@Nucleus

References
a_re1494( Apoptosis  map ):
PMID:16818236
upon UVA irradiation (no DSB), phosphorylation of H2AX S139 by JNK
effect of Y142 phosphorylation not assessed
PMID:19234442
interaction between JNK1 and H2AX Y142_pho dependent on FE65 (proposed FE65 scaffolding JNK to Y142_pho)
they propose H2AX Y142 phosphorylation as a switch toward apoptosis.
Even if not fully documented, the information from these 2 papers is merged into this representation where doubly phosphorylated H2AX cooperated with CAD for DNA fragmentation


Modifications:
In compartment: Nucleus
  1. APBB1@Nucleus map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

      As Catalyser:

      1. H2AFX|​Y142_pho@Nucleus map map H2AFX|​S139_pho|​Y142_pho@Nucleus map

      Leave a Reply