APAF1

Protein APAF1 map

Identifiers
apoptotic peptidase activating factor 1
HUGO:APAF1 HGNC:576 ENTREZ:317 UNIPROT:O14727 GENECARDS:APAF1 REACTOME:50100 KEGG:317 ATLASONC:APAF1ID422 WIKI:APAF1

Maps_Modules
 Apoptosis  map  / APOPTOSIS_GENES  map
 Apoptosis  map  / CASPASES  map
 Survival  map  / PI3K_AKT_MTOR  map

References
PMID:19788417
PMID:16977332

APAF1@Cytoplasm

References
a_re482( Apoptosis  map ):
PMID:17377525
review on apoptosome formation
PMID:11864614
stoechiometry apoptosome
PMID:12522243
inhibition of apoptosome formation by prothymosin-alpha
PMID:15087373
in HT-29 colon adenocarcinoma cells, siRNA against ACHE prevents the APAF1:CYCS interaction and etoposide-induced
PMID:14622304
AFP positive influence on apoptosome assembly
PMID:18439902
CAS PHAPI and HSP70 enhance apoptosome formation and caspase activation
a_re485:( Apoptosis  map ) PMID:10949025
a_re486( Apoptosis  map ):
PMID:10934467
in 293, HeLa and Jurkat cells, interaction HSP70 – APAF1
in vitro, the interaction is ATP dependent
HSP70 interactions competes for oligomerization and formation of the apoptosome
PMID:10934466
in vitro, HSP70 blocks the recruitment of CASP9 into the apoptosome by binding to APAF1
a_re487:( Apoptosis  map ) PMID:15262985
a_re488:( Apoptosis  map ) PMID:10944114


Modifications:
In compartment: Cytoplasm
  1. APAF1@Cytoplasm map

Participates in complexes:
In compartment: Cytoplasm

  1. APAF1:​APIP@Cytoplasm map

  2. APAF1:​AVEN@Cytoplasm map
  3. APAF1:​HSP70*@Cytoplasm map
  4. APAF1:​HSP90*@Cytoplasm map
  5. (d)ATP:​APAF1:​Cytochrome_C*|​ferroheme@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. rAPAF1@Nucleus map map APAF1@Cytoplasm map

  2. Cytochrome_C*|​ferroheme@Cytoplasm map + (d)ATP@Cytoplasm map + APAF1@Cytoplasm map map (d)ATP:​APAF1:​Cytochrome_C*|​ferroheme@Cytoplasm map
  3. APAF1@Cytoplasm map + AVEN@Cytoplasm map map APAF1:​AVEN@Cytoplasm map
  4. APAF1@Cytoplasm map + HSP70*@Cytoplasm map map APAF1:​HSP70*@Cytoplasm map
  5. APAF1@Cytoplasm map + APIP@Cytoplasm map map APAF1:​APIP@Cytoplasm map
  6. APAF1@Cytoplasm map + HSP90*@Cytoplasm map map APAF1:​HSP90*@Cytoplasm map

As Catalyser:

  1. Caspase9*@Cytoplasm map map cleaved~Caspase9*@Cytoplasm map

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