AP-1_ARRE binding sites*:FOS:JUN:NFAT*

Complex AP-1_ARRE binding sites*:FOS:JUN:NFAT* map


Complex composition:

  1. JUN map
  2. FOS map
  3. AP-1_ARRE binding sites* map
  4. NFAT* map




AP-1_ARRE binding sites*:​FOS:​JUN:​NFAT*@Nucleus

Identifiers
NAME:AP-1_ARRE binding sites*:FOS:JUN:NFAT*

Maps_Modules
 Survival  map  / WNT_NON_CANONICAL  map

References
PMID:11402342
s_wnc3_re31( Survival  map ):
Phosphorylation of NFAT leads to increased DNA binding of NFAT -> increased gene transcription
PMID15657416
Not sure if dissociation of calcineurin and ERK/MEK occurs
s_wnc3_re27( Survival  map ):
NFAT1 together with JUN/FOS=AP-1 activates the promoter of GPC6
PMID:21871017

Confidence
REF=1 FUNC=4


Modifications:
Participates in complexes:
In compartment: Nucleus
  1. AP-1_ARRE binding sites*:​FOS:​JUN:​NFAT*@Nucleus map

Participates in reactions:
As Reactant or Product:

  1. CNA*:​CNB*:​ERK2*:​MEK1*:​NFAT*|​pho@Nucleus map + gAP-1_ARRE binding sites*@Nucleus map + JUN@Nucleus map + FOS@Nucleus map map AP-1_ARRE binding sites*:​FOS:​JUN:​NFAT*@Nucleus map + CNA*:​CNB*@Nucleus map + ERK2*@Nucleus map + MEK1*@Nucleus map

  2. gAP-1_ARRE binding sites*@Nucleus map + JUN@Nucleus map + FOS@Nucleus map + NFAT*@Nucleus map map AP-1_ARRE binding sites*:​FOS:​JUN:​NFAT*@Nucleus map

As Catalyser:

  1. gGPC6@Nucleus map map rGPC6@Nucleus map

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