AMP:PKA_R*:PRKAA*:PRKAG*

Complex AMP:PKA_R*:PRKAA*:PRKAG* map


Complex composition:

  1. PRKAA* map
  2. AMP map
  3. PRKAG* map
  4. PKA_R* map




AMP:​PKA_R*:​PRKAA*:​PRKAG*@Cytoplasm

Identifiers
NAME:AMP:PKA_R*:PRKAA*:PRKAG*

References
a_re335( Apoptosis  map ):
PMID:15509864
review
a_re334( Apoptosis  map ):
PMID:16054095
by CAMKK2
PMID:16054096
PMID:17244528
by calcium via CAMKK2 and AMPK
PMID:15980064
by CAMKK
PMID:18692468
propose that SESN2 promotes AMPK autophosphorylation, thus increasing TSC1/2 activity.
PMID:19197243
in RPE1-hTERT mouse inner medullary collecting duct cells, in MEFs, in MCF10A, by TAK1, upon TRAIL exposure
in MCF10A upon Ca2+ by CAMKK2
a_re336( Apoptosis  map ):
PMID:8910387
by LKB1, from rat enzyme
LKB1 dependent AMPK phosphorylation induced by glucose starvation
in MCF10A upon starvation by LKB1
PMID:20160076
in EBV-immortalized B-lymphocytes from healthy individuals, but not from ATM-deficient AT patients, upon H2O2

Confidence
REF=5 FUNC=4

AMP:​PKA_R*:​PRKAA*|​T172_pho:​PRKAG*@Cytoplasm

Identifiers
NAME:AMP:PKA_R*:PRKAA*:PRKAG*

References
a_re334( Apoptosis  map ):
PMID:15509864
review
PMID:16054095
by CAMKK2
PMID:16054096
PMID:17244528
by calcium via CAMKK2 and AMPK
PMID:15980064
by CAMKK
PMID:18692468
propose that SESN2 promotes AMPK autophosphorylation, thus increasing TSC1/2 activity.
PMID:19197243
in RPE1-hTERT mouse inner medullary collecting duct cells, in MEFs, in MCF10A, by TAK1, upon TRAIL exposure
in MCF10A upon Ca2+ by CAMKK2
a_re336( Apoptosis  map ):
PMID:8910387
by LKB1, from rat enzyme
LKB1 dependent AMPK phosphorylation induced by glucose starvation
in MCF10A upon starvation by LKB1
PMID:20160076
in EBV-immortalized B-lymphocytes from healthy individuals, but not from ATM-deficient AT patients, upon H2O2
a_re271( Apoptosis  map ):
PMID:16115917
phosphorylation at S461 (isoform PFKFB3-ACG) in different tumor cells
in COS-7, expression of a phosphomimetic mutant enhances glycolysis
PMID:17712357
by AMPK review
a_re273:( Apoptosis  map ) PMID:11069105
a_re352( Apoptosis  map ):
PMID:14651849
PMID:19339977
SESN2 promotes TSC2 phosphorylation, and interacts with both AMPK and TSC2.
a_re370( Apoptosis  map ):
PMID:18439900
in HEK293
a_re1068( Apoptosis  map ):
PMID:9029219
PMID:16326698

Confidence
REF=5 FUNC=4


Modifications:
Participates in complexes:
In compartment: Cytoplasm
  1. AMP:​PKA_R*:​PRKAA*:​PRKAG*@Cytoplasm map

  2. AMP:​PKA_R*:​PRKAA*|​T172_pho:​PRKAG*@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. AMP:​PKA_R*:​PRKAA*:​PRKAG*@Cytoplasm map map AMP:​PKA_R*:​PRKAA*|​T172_pho:​PRKAG*@Cytoplasm map

  2. ATP:​PKA_R*:​PRKAA*:​PRKAG*@Cytoplasm map + AMP@Cytoplasm map map AMP:​PKA_R*:​PRKAA*:​PRKAG*@Cytoplasm map + ATP@Cytoplasm map
  3. AMP:​PKA_R*:​PRKAA*:​PRKAG*@Cytoplasm map map AMP:​PKA_R*:​PRKAA*|​T172_pho:​PRKAG*@Cytoplasm map

As Catalyser:

  1. ACACA@Cytoplasm map map ACACA|​S79_pho@Cytoplasm map

  2. PFKFB3@Cytoplasm map map PFKFB3|​pho@Cytoplasm map
  3. PFKFB2@Cytoplasm map map PFKFB2|​pho@Cytoplasm map
  4. TSC1:​TSC2|​M1_unk@Cytoplasm map map TSC1:​TSC2|​S1345_pho|​M1_unk@Cytoplasm map
  5. RPTOR@Cytoplasm map map RPTOR|​S722_pho|​S792_pho@Cytoplasm map

Leave a Reply