AMER1*:AXIN*:CK1_alpha_*:CK1_gamma_*:DVL*:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:PRR*:WNT*:_beta_-Arrestin2*

Complex AMER1*:AXIN*:CK1_alpha_*:CK1_gamma_*:DVL*:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:PRR*:WNT*:_beta_-Arrestin2* map


Complex composition:

  1. PRR* map
  2. FZD* map
  3. DVL* map
  4. G_alpha_o* map
  5. AXIN* map
  6. GSK3* map
  7. CK1_alpha_* map
  8. G_beta_* map
  9. G_gamma_* map
  10. LRP5_6* map
  11. CK1_gamma_* map
  12. _beta_-Arrestin2* map
  13. AMER1* map
  14. WNT* map




AMER1*:​AXIN*:​CK1_alpha_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome

Identifiers
NAME:AMER1*:AXIN*:CK1_alpha_*:CK1_gamma_*:DVL*:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:PRR*:WNT*:_beta_-Arrestin2*

Maps_Modules
 Survival  map  / WNT_CANONICAL  map

References
PMID:52226983 PMID:21606194 PMID:20460648
s_wca1_re43( Survival  map ):
PMID:21606194 PMID:21285348
DVL is again phosphorylated to form PS-DVL. This isoform of DVL leads to depolimerisation of DVL and even distribution in the cell. Which CK1 isoform catalyses this reaction is unknown

Confidence
REF=3 FUNC=3


Modifications:
Participates in complexes:
In compartment: Endosome
  1. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome map

Participates in reactions:
As Reactant or Product:

  1. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*|​S268_pho|​S269_pho@Endosome map map CK1_epsilon_*:​p120*|​S268_pho|​S269_pho@Endosome map + E-Cadherin*|​pho@Endosome map + AMER1*:​AXIN*:​CK1_alpha_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome map

  2. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome map map AMER1*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho|​pho:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome map + AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Endosome map

As Catalyser:

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