Alkylating agents*

Simple molecule Alkylating agents* map
Alkylating agents*@Nucleus

Identifiers
Nitrogen mustards
Cyclophosphamide
Mechlorethamine or mustine (HN2) (trade name Mustardgen)
Uramustine or uracil mustard
Melphalan
Chlorambucil
Ifosfamide
Nitrosoureas
Carmustine
Lomustine
Streptozocin
Alkyl sulfonates
Busulfan

Maps_Modules
 DNA repair  map  / BER  map
 DNA repair  map  / NER  map
 DNA repair  map  / DR  map
 DNA repair  map  / MMR  map

References
PMID:22237395, PMID:22122467, PMID:21113301, PMID:22911013, PMID:22788764, PMID:22709253
d_re511( DNA repair  map ):
http://dnatraffic.ibb.waw.pl/classification/dna_damages
PMID:22258607, PMID:19267553, PMID:18256616
For BER activation by IR
PMID:19414382, PMID:21204762, PMID:20832016, PMID:17892593
For BER activation by ROS
PMID:23249296, PMID:22122466, PMID:20510258, PMID:21251944, PMID:23311711
d_re515( DNA repair  map ):
FOR HR activation by IR
PMID:20723763
For HR activation by UV
PMID:21885354, PMID:22987150, PMID:20206282, PMID:19398948, PMID:1575062
Interstrand crosslinking agents activate HR
PMID:21701511
Topoisomerate inhibitors bloch double strand DNA repair by HR, C_NHEJ and Fanconi pathways
PMID:23259582
For HR
PMID:22123462, PMID:20693240
FOR Fanconi
PMID:21414716, PMID:23157317
For activation by Dbait
PMID:22068457, PMID:22815765, PMID:22042585, PMID:19621083
d_re516( DNA repair  map ):
For actovation of TLS by UV
PMID:22521143
For actIvation of TLS by interstrand crosslinking agents
PMID:20015866, PMID:15155842, PMID:22122464, PMID:23106263, PMID:21666254, PMID:20658647
d_re517( DNA repair  map ):
UV light causes bulky adducts damage in DNA that repared by NER pathway
For activation of NER by UV
PMID:22743272, PMID:22822215, PMID:22492724, PMID:22373527
Interstrand crosslinking agents induce NER
ROS activate NER for repating intrastrand crosslink
PMID:22581771
ROS activate NER for bulky adducts
PMID:18189366
d_re518( DNA repair  map ):
Damage caused by UV light pyrimidine dimers is repaired by DR
d_re519( DNA repair  map ):
PMID:22743272, PMID:22822215, PMID:22492724, NER:22373527
Transcription-dependent NER and damage by UV
PMID:20045328, PMID:14599741
d_re527( DNA repair  map ):


Modifications:
In compartment: Nucleus
  1. Alkylating agents*@Nucleus map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

      As Catalyser:

      1. gIntact_DNA*@Nucleus map map gDeaminated_alkylated_mismatched_base*@Nucleus map

      2. gIntact_DNA*@Nucleus map map gHR_DNA_st1*@Nucleus map
      3. gIntact_DNA*@Nucleus map map gTLS_DNA_st1*@Nucleus map
      4. gIntact_DNA*@Nucleus map map gGG-NER_DNA_st1*@Nucleus map
      5. gIntact_DNA*@Nucleus map map gDR_DNA_st1*@Nucleus map
      6. gIntact_DNA*@Nucleus map map gTC-NER_DNA_st1*@Nucleus map
      7. gIntact_DNA*@Nucleus map map gOxidized_ring-saturated_hydrolysed_base*@Nucleus map
      8. gIntact_DNA*@Nucleus map map gMismatched_nucleotide*@Nucleus map

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