AKT1

Protein AKT1 map

Identifiers
v-akt murine thymoma viral oncogene homolog 1
HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 GENECARDS:AKT1 REACTOME:58253 KEGG:207 ATLASONC:AKT1ID355ch14q32 WIKI:AKT1

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 Apoptosis  map  / AKT_MTOR  map
 Cell cycle  map  / APOPTOSIS_ENTRY  map
 Cell cycle  map  / CYCLIND  map
 Cell cycle  map  / P21CIP  map
 Cell cycle  map  / P27KIP  map
 Survival  map  / PI3K_AKT_MTOR  map
 Survival  map  / WNT_NON_CANONICAL  map

References
PMID:20214616
PMID:17680028
PMID:20398329

AKT1@Cytoplasm

References
e_re458( EMT  map ):
PMID:7945242
PMID:8524413
AKT (PKB) phosphorylates GSK3B at Serine residue and inactivate GSK3B
e_re1271( EMT  map ):
PMID:19153598
AKT1 blocks Apoptosis
e_re1610( EMT  map ):
PMID:12175651
PMID:10826997
PMID:12767520
PMID:19030972
PMID:16931767
PMID:21540285
PMID:12444011
IGFfamily exhibits anti-apoptotic activity.
Three IGF1R-induced anti-apoptotic pathways:
1. IRS1-mediated pathway causing activation of PI3K and AKT(PKB) leading to BAD phosphorylation.
Unphosphorylated BAD, by binding to BCLXL and BCL2, neutralizes the protective effect of these 2 later proteins and promotes cell death.
Phosphorylated BAD is sequestered by 14-3-3 protein family and thus unable to bind BCL2 family hence can not promote cell death.
2. After autophosphorylation and thus activation, IGF1R binds to 14-3-3 protein family, leading to activation and translocation of c-Raf1 to the mitochondria where it phosphorylates BAD.
3. IGF1R specifically phosphorylates and inhibits ASK1 (MAP3K5)

AKT1@Nucleus

References
c_re155:( Cell cycle  map ) PMID:10385618, PMID:12459251
c_re157( Cell cycle  map ):
Phosphorylations on p53 prevent its binding to MDM2.
PMID:15140942
MDM2 phosphorylation by AKT favors the binding of MDM2 to p53 and its following degradation.
PMID:15574337
c_re269( Cell cycle  map ):
Phosphorylation of p27 at Thr-157 by AKT-1 induce its cytoplasmic localization.
PMID:12851486
c_re604( Cell cycle  map ):
Phosphorylation at T145 is catalyzed by the protein serine/threonine kinase Akt
PMID:16775416, PMID:15798220
Phosphorylation of p21 at Thr-145 by AKT-1 induce its cytoplasmic localization.
PMID:11231573

AKT1|​T450_pho|​S473_emp|​active@Cytoplasm

References
s_akt1_re24:( Survival  map ) PMID:18042541 PMID:18077353

AKT1|​T450_emp|​S473_emp|​S129_emp@Cytoplasm

References
s_akt1_re40:( Survival  map ) PMID:19662498

AKT1|​T450_emp|​S473_emp|​S129_pho@Cytoplasm

References
s_akt1_re40:( Survival  map ) PMID:19662498
s_akt1_re41( Survival  map ):
PMID:19662498
PMID:19387550
PMID:18566586

AKT1|​T308_pho|​T450_pho|​S473_pho|​active@Nucleus

References
s_akt1_re103:( Survival  map ) PMID:11154281
s_akt1_re119( Survival  map ):
PMID:15169778
PMID:11923280
PMID:11715018

AKT1|​pho@Cytoplasm

References
s_wnc1_re1( Survival  map ):
PMID:21506126
PAR1 can induce AKT phosphorylation; exact mechanism unknown also wich residues are unknown
PMID:17374729
s_wnc1_re2( Survival  map ):
Phosphorylation of beta-catenin is through an indirect mechanism which is unknown
PMID:21303971
Path to phosphorylation of b-catenin is not completely depicted here. For full paths see AKT-MODULE
s_s_wnc1_re2( Survival  map ):

AKT1|​pho|​active@Cytoplasm

References
s_wnc1_re23:( Survival  map ) PMID:9859994
s_wnc1_re123( Survival  map ):
Akt phosphorylates POSH in the Rac1 binding domain, preventing binding of Rac1 w/ POSH
PMID:17535800


Modifications:
In compartment: Cytoplasm
  1. AKT1@Cytoplasm map

  2. AKT1|​pho@Cytoplasm map
  3. AKT1|​pho|​active@Cytoplasm map
  4. AKT1|​T450_pho|​S473_emp|​active@Cytoplasm map
  5. AKT1|​T450_emp|​S473_emp|​S129_emp@Cytoplasm map
  6. AKT1|​T450_emp|​S473_emp|​S129_pho@Cytoplasm map

In compartment: Nucleus

  1. AKT1@Nucleus map

  2. AKT1|​T308_pho|​T450_pho|​S473_pho|​active@Nucleus map

Participates in complexes:
In compartment: Lipid Raft

  1. AKT1|​T308_pho|​T450_pho|​S473_emp:​PI3,4,5-P3@Lipid Raft map

  2. AKT1|​T308_pho|​T450_pho|​S473_pho:​PI3,4,5-P3@Lipid Raft map

Participates in reactions:
As Reactant or Product:

  1. AKT1@Cytoplasm map map cleaved~AKT1*@Cytoplasm map

  2. AKT1@Cytoplasm map map AKT*@Cytoplasm map
  3. AKT1@Cytoplasm map map Apoptosis@Cytoplasm map
  4. AKT1@Cytoplasm map map NF-_kappa_B_p65*@Cytoplasm map
  5. AKT1@Cytoplasm map map AKT1@Cytoplasm map
  6. AKT1|​T308_pho|​T450_pho|​S473_pho:​PI3,4,5-P3@Lipid Raft map map AKT1|​T308_pho|​T450_pho|​S473_pho|​active@Nucleus map
  7. AKT1|​T308_pho|​T450_pho|​S473_pho:​PI3,4,5-P3@Lipid Raft map map AKT1|​T308_pho|​T450_pho|​S473_emp:​PI3,4,5-P3@Lipid Raft map
  8. PI3,4,5-P3@Lipid Raft map + AKT1|​T450_pho|​S473_emp|​active@Cytoplasm map map AKT1|​T308_pho|​T450_pho|​S473_emp:​PI3,4,5-P3@Lipid Raft map
  9. AKT1|​T308_pho|​T450_pho|​S473_emp:​PI3,4,5-P3@Lipid Raft map map AKT1|​T308_pho|​T450_pho|​S473_pho:​PI3,4,5-P3@Lipid Raft map
  10. AKT1|​T450_emp|​S473_emp|​S129_emp@Cytoplasm map map AKT1|​T450_pho|​S473_emp|​active@Cytoplasm map
  11. AKT1|​T308_pho|​T450_pho|​S473_emp:​PI3,4,5-P3@Lipid Raft map map AKT1|​T450_pho|​S473_emp|​active@Cytoplasm map
  12. AKT1|​T450_emp|​S473_emp|​S129_emp@Cytoplasm map map AKT1|​T450_emp|​S473_emp|​S129_pho@Cytoplasm map
  13. AKT1|​T450_emp|​S473_emp|​S129_pho@Cytoplasm map + HSP90*@Cytoplasm map map s_s_akt1_s132
  14. s_s_akt1_s132 map AKT1|​T308_pho|​T450_pho|​S473_pho:​PI3,4,5-P3@Lipid Raft map
  15. AKT1@Cytoplasm map map AKT1|​pho@Cytoplasm map
  16. AKT1@Cytoplasm map map AKT1|​pho|​active@Cytoplasm map
  17. AKT1|​pho|​active@Cytoplasm map map PI3K AKT MTOR pathway@Cytoplasm map

As Catalyser:

  1. GSK3_beta_*@Nucleus map map GSK3_beta_*|​pho@Nucleus map

  2. MDM2@Nucleus map + p53*@Nucleus map map c_s731
  3. p27KIP1*@Nucleus map map p27KIP1*|​Thr157_pho@Nucleus map
  4. p21CIP1*@Nucleus map map p21CIP1*|​T145_pho@Nucleus map
  5. MDM2@Nucleus map map MDM2|​S186_pho@Nucleus map
  6. BAD@Mitochondria map map BAD|​pho@Mitochondria map
  7. FOXO3@Nucleus map map FOXO3|​pho@Nucleus map
  8. rp21CIP1*@Nucleus map map p21CIP1*@Cytoplasm map
  9. GSK3_beta_*@Cytoplasm map map GSK3_beta_*|​S_pho@Cytoplasm map
  10. FOXO3|​S315_pho@Nucleus map map FOXO3|​T32_pho|​S253_pho|​S315_pho@Nucleus map
  11. GSK3_beta_*@Cytoplasm map map GSK3_beta_*|​pho@Cytoplasm map
  12. MDM2|​S166_emp@Cytoplasm map map MDM2|​S166_pho|​pho@Cytoplasm map
  13. MDM2|​S166_pho|​pho@Nucleus map map MDM2|​S166_pho|​pho|​S188_pho@Nucleus map
  14. s_s_akt1_s533 map s_s_akt1_s528
  15. 14-3-3*:​BAD|​S112_pho|​S136_pho@Mitochondria map map 14-3-3*:​BAD|​S112_pho|​S136_pho|​S155_pho@Mitochondria map
  16. ENOS*@Cytoplasm map map ENOS*|​pho@Cytoplasm map
  17. Caspase9*@Cytoplasm map map Caspase9*|​pho@Cytoplasm map
  18. p21CIP1*@Cytoplasm map map p21CIP1*|​T145_pho@Cytoplasm map
  19. p21CIP1*|​T145_pho@Cytoplasm map map p21CIP1*|​pho|​T146_pho@Cytoplasm map
  20. s_s_akt1_s816 map s_s_akt1_s822
  21. AKT1|​T308_pho|​T450_pho|​S473_emp:​PI3,4,5-P3@Lipid Raft map map AKT1|​T308_pho|​T450_pho|​S473_pho:​PI3,4,5-P3@Lipid Raft map
  22. TSC1:​TSC2@Endosome Membrane map map TSC1:​TSC2|​S981_pho|​S1130_pho|​pho|​S1132_pho|​pho|​S1088_pho|​S1086_pho@Endosome Membrane map
  23. MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome map map MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome map
  24. p27KIP1*|​S10_pho@Cytoplasm map map p27KIP1*|​S10_pho|​T187_emp|​pho|​pho@Cytoplasm map
  25. POSH*@Cytoplasm map map POSH*|​S304_pho@Cytoplasm map
  26. _beta_-Catenin*@Cytoplasm map map _beta_-Catenin*|​S522_pho@Cytoplasm map

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