AKT*

Protein AKT* map

Identifiers
v-akt murine thymoma viral oncogene homolog 1
HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 GENECARDS:AKT1 REACTOME:58253 KEGG:207 ATLASONC:AKT1ID355ch14q32 WIKI:AKT1
v-akt murine thymoma viral oncogene homolog 2
HUGO:AKT2 HGNC:392 ENTREZ:208 UNIPROT:P31751 GENECARDS:AKT2 REACTOME:49860 KEGG:208 ATLASONC:AKT2ID517ch19q13 WIKI:AKT2
v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
HUGO:AKT3 HGNC:393 ENTREZ:10000 UNIPROT:Q9Y243 GENECARDS:AKT3 REACTOME:415917 KEGG:10000 ATLASONC:AKT3ID615ch1q44 WIKI:AKT3
HUGO:AKT3 HGNC:393 ENTREZ:10000 UNIPROT:Q9Y243 GENECARDS:AKT3 REACTOME:415917 KEGG:10000 ATLASONC:AKT3ID615ch1q44 WIKI:AKT3 HUGO:CDH2 HGNC:1759 ENTREZ:1000 UNIPROT:P19022 GENECARDS:CDH2 REACTOME:51212 KEGG:1000 ATLASONC:GC_CDH2 WIKI:CDH2

Maps_Modules
 Apoptosis  map  / AKT_MTOR  map
 Apoptosis  map  / CASPASES  map
 Apoptosis  map  / MITOCH_METABOLISM  map
 Apoptosis  map  / MOMP_REGULATION  map
 DNA repair  map  / G1_S_CHECKPOINT  map
 Survival  map  / HEDGEHOG  map
 Survival  map  / MAPK  map
 Survival  map  / PI3K_AKT_MTOR  map
 Survival  map  / WNT_NON_CANONICAL  map

References
PMID:20214616
PMID:17680028
PMID:20398329

AKT*|​S473_pho|​T308_pho@Cytoplasm

References
a_re631( Apoptosis  map ):
logical:re631_s3146_re638=FALSE
PMID:9381178
in FL5.12 (murine pro-B-cell lymphoid cell, IL-3 dependent) BAD phosphorylated upon IL-3
in 293T, over-expression of wt Akt or myr-Akt, but not kinase mutant induces phosphorylation of BAD
in vitro phosphorylation of BAD by Akt, BAD S112(human S75)A-S136(human S99)A not phosphorylated
PMID:8929531
2D tryptic peptide mapping identifies S112(human S75) and S136(human S99) as the phospho-sites
phsophorylation in FL5.12 in response to IL-3 or PMA
PMID:9346240
in vitro, purified Akt phosphorylates recombinant BAD at S136(human S99) but not at S112(human S75) (serine mutants)
in Balb/c 3T3 upon PDGF or PC12 upon NGF, BAD phosphorylated in an Akt-dependent manner (wortmannin, LY294002)
partial evidence for BAD:Akt interaction
PMID:10230394
mitochondria localized PKA is a BAD-S112(human S75) kinase
PMID:10558990
in vitro purified activated RSK2/RPS6KA3 phosphorylates a peptide encompassing BAD S112(humanS75) phospho-site. Far less efficient as a BAD-S136 kinase
in 293T, over-expression of RSK2 and MEK1 induces phsophorylation of BAD (anti-BAD pS112)
in BDNF-treated cerebellar granule cells, BDNF induces S112 phosphorylation of BAD, in a MEK1-dependent manner (PD098059)
PMID:10837486
RSK is a BAD S112 kinase (anti BAD-phosphoS112)
in vitro,
in HEK293 upon forskolin TPA isoproterenol or insulin-like growth factor, PKA mediated phosphorylation of S155 of murine BAD (human S118)
S118 lies in the BH3 domain of BAD
phosphorylation of S155 independent of that of S112/136
RSK1-2-3 are BAD S155 kinases
PMID:12954615
in vitro, murine PIM2 immunoprecipitated from trasfected U2OS phosphorylates BAD
in U2OS, PIM2 expression but not that of a kinase dead mutant induces BAD S112 phosphorylation
in FDCP1 murine IL3 dependent hematopoietic cells, upon IL3 withdrawal or doxorubicin, PIM2 ectopic expression is protective
PMID:15280015
BAD S112 phosphorylation by PIM1
PMID:17270021
in SW480 human colon carcinoma cell line, correlation between PIM3 expression and BAD phosphorylation. siRNA against PIM3 abrogates BAD S112 and S136 phosphorylation and induces apoptosis
in a set of human colon cancers, correlation and colocalization of PIM3 and BAD phospho-S112
PMID:11493700
S6K purified as a BAD kinase from FL5.12 BCL-XL/BAD cells
in vitro with recombinant proteins, BAD S136 phosphorylation
in FL5.12 by S6K upon IGF, inhibited by rapamycin
in ES p70S6K-/- cells, IGF-induced BAD S136 phosphorylation is lost
PMID:10611223
in FL5.12 upon IL3, PAK1 phosphorylates BAD on S112 and S136, which results in decreased interaction with BCL2 and BCL2L1, and increased interaction with 14-3-3

AKT*@Cytoplasm

References
a_re1238:( Apoptosis  map ) reactionType:is.a
a_re328( Apoptosis  map ):
PMID:19203586
PHLDA3 competes with the PH domain of Akt for binding of membrane lipids, thereby inhibiting Akt translocation to the cellular membrane and activation
PMID:15718470
TORC2 complex as AKT S473 kinase

AKT*|​S473_unk|​T308_unk@Cytoplasm

References
a_re719:( Apoptosis  map ) reactionType:is.a
a_re721:( Apoptosis  map ) PMID:12176997

AKT*|​S473_unk|​T308_unk|​unfolded@Cytoplasm

References
a_re721:( Apoptosis  map ) PMID:12176997

AKT*|​pho@Cytoplasm

References
s_mpk1_re267( Survival  map ):
PDK1 is a PI3K target leading to activation of P70 and subsequent cell growth. Signaling proteins with pleckstrin-homology (PH) domains accumulate at sites of PI3K activation by directly binding to PI(345)P3. Of particular interest are the protein serine-threonine kinases Akt and phosphoinositide-dependent kinase 1 (PDK1). Association with PI(345)P3 at the membrane brings these proteins into proximity and facilitates phosphorylation of Akt by PDK1. This phosphorylation stimulates the catalytic activity of Akt resulting in the phosphorylation of a host of other proteins that affect cell growth cell cycle entry and cell survival.
PMID:12040186
s_mpk1_re262( Survival  map ):
JNK phosphorylates MST1 at serine 82 which leads to the enhancement of MST1 activation. The activation of MST1 phosphorylates FOXO3 at serine 207 and promotes cell death.
Phosphorylation of FOXO3 by Akt creates a binding site for the 14-3-3 family of proteins. The complex of FOXO3 and 14-3-3 is retained in the cytosol blocking transcription of genes normally stimulated by FOXO3.
PMID:20028971 PMID:12040186
s_mpk1_re269( Survival  map ):
P21 is a direct substrate of AKT and this may regulate the subcellular localisation of P21. Phosphorylation of P21 by AKT correlated with its exit from the nucleus and with increased cell cycle progression.
PMID:11882383
s_mpk1_re270( Survival  map ):
Akt phosphorylation of the apoptosis-inducing protein BAD creates a binding site for 14-3-3 proteins and prevents BAD from binding to Bcl-2 family members Bcl-2 and Bcl-XL thus releasing them for a cell survival response.
s_mpk1_re271( Survival  map ):
Glycogen synthase kinase 3 (GSK3) is a target of Akt. This protein kinase is constitutively active in unstimulated cells and phosphorylates many proteins (including glycogen synthase C-MYC and cyclin D) to keep them in inactive states or promote their degradation. Phosphorylation of GSK3 (both alpha and beta isoforms) by Akt turns off the catalytic activity of this enzyme resulting in the activation of pathways that are normally repressed by GSK3.
s_wnc2_re4( Survival  map ):
PMID:21506126, PMID:21303971
Path to phosphorylation of b-catenin is not completely depicted here. For full paths see AKT-pathway
Activated CaSR inhibits phosphorylation of b-catenin, exact mechanism unknown
PMID:22094462
s_wnc2_re54:( Survival  map ) PMID:18218901
s_s_mpk1_re270( Survival  map ):
s_s_mpk1_re271( Survival  map ):

AKT*|​pho|​pho|​pho|​active@Nucleus

References
s_akt2_re28( Survival  map ):
PMID:16680151
PMID:20452955
PMID:19216069
s_akt2_re66:( Survival  map ) PMID15169778
s_akt2_re89:( Survival  map ) PMID:17646672
s_akt2_re113:( Survival  map ) PMID:10217147
s_akt2_re144:( Survival  map ) PMID:11463845 PMID:11756412
s_akt2_re152:( Survival  map ) PMID:9829964

AKT*|​emp|​pho|​pho@Nucleus

References
s_akt2_re28( Survival  map ):
PMID:16680151
PMID:20452955
PMID:19216069


Modifications:
In compartment: Cytoplasm
  1. AKT*@Cytoplasm map

  2. AKT*|​pho@Cytoplasm map
  3. AKT*|​pho@Cytoplasm map
  4. AKT*|​S473_pho|​T308_pho@Cytoplasm map
  5. AKT*|​S473_unk|​T308_unk@Cytoplasm map
  6. AKT*|​S473_unk|​T308_unk|​unfolded@Cytoplasm map

In compartment: Nucleus

  1. AKT*|​emp|​pho|​pho@Nucleus map

  2. AKT*|​pho|​pho|​pho|​active@Nucleus map

In compartment: default

  1. AKT*@default map

Participates in complexes:
In compartment: Cytoplasm

  1. AKT*|​pho|​T450_pho:​PI3,4,5-P3@Cytoplasm map

  2. AKT*|​pho|​T450_pho|​pho:​PI3,4,5-P3@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. AKT1@Cytoplasm map map AKT*@Cytoplasm map

  2. AKT2@Cytoplasm map map AKT*@Cytoplasm map
  3. AKT*@Cytoplasm map map AKT*|​S473_pho|​T308_pho@Cytoplasm map
  4. AKT*|​S473_pho|​T308_pho@Cytoplasm map map AKT*|​S473_unk|​T308_unk@Cytoplasm map
  5. AKT*@Cytoplasm map map AKT*|​S473_unk|​T308_unk@Cytoplasm map
  6. AKT*|​S473_unk|​T308_unk@Cytoplasm map map AKT*|​S473_unk|​T308_unk|​unfolded@Cytoplasm map
  7. AKT*|​pho|​pho|​pho|​active@Nucleus map map AKT*|​emp|​pho|​pho@Nucleus map
  8. AKT*@Cytoplasm map map AKT*|​pho@Cytoplasm map
  9. AKT*|​pho|​T450_pho:​PI3,4,5-P3@Cytoplasm map map AKT*|​pho|​T450_pho|​pho:​PI3,4,5-P3@Cytoplasm map
  10. PI3K AKT MTOR pathway@Cytoplasm map map AKT*|​pho|​T450_pho:​PI3,4,5-P3@Cytoplasm map

As Catalyser:

  1. p27KIP1*@Nucleus map map p27KIP1*|​T198_pho|​T157_pho@Nucleus map

  2. BAX@Cytoplasm map map BAX|​S184_pho@Cytoplasm map
  3. ACLY@Cytoplasm map + ATP@Cytoplasm map map ACLY|​S454_pho@Cytoplasm map + ADP@Cytoplasm map
  4. GSK3_beta_*@Cytoplasm map map GSK3_beta_*|​S9_pho@Cytoplasm map
  5. GSK3_alpha_*@Cytoplasm map map GSK3_alpha_*|​S21_pho@Cytoplasm map
  6. FOXO*@Cytoplasm map map FOXO*|​pho|​pho@Cytoplasm map
  7. TSC1:​TSC2|​M1_unk@Cytoplasm map map TSC1:​TSC2|​S939_pho|​T1462_pho|​M1_unk@Cytoplasm map
  8. MLST8:​MTOR:​PRAS40*:​RPTOR@Cytoplasm map map MLST8:​MTOR:​PRAS40*|​pho:​RPTOR@Cytoplasm map
  9. BimEL*@Cytoplasm map map BimEL*|​S87_pho@Cytoplasm map
  10. SNAP23:​STX4:​STXBP4@Cytoplasm map map STXBP4|​S99_pho@Cytoplasm map + SNAP23:​STX4@Cytoplasm map
  11. SLC2A1@Secretory Granule map map SLC2A1@Cytoplasm map
  12. XIAP@Cytoplasm map map XIAP|​S87_pho@Cytoplasm map
  13. Caspase9*|​T125_unk|​S144_unk|​Y153_unk@Cytoplasm map map Caspase9*|​S196_pho|​T125_unk|​S144_unk|​Y153_unk@Cytoplasm map
  14. BAD@Cytoplasm map map BAD|​pho@Cytoplasm map
  15. FOXO*|​unk@default map map FOXO*@default map
  16. FOXO4@Nucleus map map FOXO4|​T28_pho|​S193_pho|​S258_pho@Nucleus map
  17. c_s771 map p21CIP1*|​pho@Nucleus map
  18. p21CIP1*|​pho@Nucleus map map p21CIP1*|​pho|​pho@Nucleus map
  19. CREB*@Nucleus map map CREB*|​pho@Nucleus map
  20. FOXO1@Nucleus map map FOXO1|​T24_pho|​S256_pho|​S319_pho@Nucleus map
  21. FOXO3|​pho:​promoter_region@Nucleus map map FOXO3|​pho|​pho|​pho:​promoter_region@Nucleus map
  22. MDM2|​pho|​pho@Nucleus map map MDM2|​pho|​pho|​pho@Nucleus map
  23. s_s_akt2_s228 map FOXO1|​T24_pho|​S256_pho|​S319_pho:​promoter_region@Nucleus map
  24. FOXO3@Cytoplasm map map FOXO3|​pho@Nucleus map
  25. c_s771 map p21CIP1*|​pho@Cytoplasm map
  26. s_s_mpk1_s953 map BCL2@Mitochondria map + BAD@Mitochondria map
  27. GSK3_beta_*@Cytoplasm map map GSK3_beta_*|​pho@Cytoplasm map
  28. AKAP*:​PKA*@Primary Cilium map map PKA*@Primary Cilium map + AKAP*@Primary Cilium map
  29. GSK3_beta_*@Cytoplasm map map GSK3_beta_*|​pho|​active@Cytoplasm map
  30. _beta_-Catenin*@Cytoplasm map map _beta_-Catenin*|​S552_pho@Cytoplasm map
  31. HOMER3@Cytoplasm map map HOMER3|​T36_pho|​S38_pho|​S52_pho@Cytoplasm map

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