AIFM1

Protein AIFM1 map

Identifiers
apoptosis-inducing factor, mitochondrion-associated, 1
HUGO:AIFM1 HGNC:8768 ENTREZ:9131 UNIPROT:O95831 GENECARDS:AIFM1 KEGG:9131 ATLASONC:AIFM1ID44053chXq25 WIKI:AIFM1

Maps_Modules
 Apoptosis  map  / MITOCH_METABOLISM  map

References
synonym:AIF
NOTE: * means carbonylated

AIFM1@Mitochondrial inner membrane

References
a_re732:( Apoptosis  map ) reactionType:is.a
a_re723( Apoptosis  map ):
PMID:15775970
AIF as an inner membrane protein that is cleaved and released into the intermembrane space upon apoptosis induction
PMID:15590628
calpain 1 mediated processing
PMID:15933737
cathepsins and calpain 1
PMID:11278689
flavin not necessary for apoptotic function
a_re730( Apoptosis  map ):
PMID:20043986
in isolated mitochondria, Ca2+-dependent and ROS-mediated carbonylation of AIF.
carbonylated AIF as a prefered substrate for calpains

AIFM1|​don@Mitochondrial inner membrane

References
a_re730( Apoptosis  map ):
PMID:20043986
in isolated mitochondria, Ca2+-dependent and ROS-mediated carbonylation of AIF.
carbonylated AIF as a prefered substrate for calpains
a_re731( Apoptosis  map ):
PMID:15775970
cleavage of AIF
a_re732:( Apoptosis  map ) reactionType:is.a


Modifications:
In compartment: Mitochondrial inner membrane
  1. AIFM1@Mitochondrial inner membrane map

  2. AIFM1|​don@Mitochondrial inner membrane map

Participates in complexes:
In compartment: Mitochondrial inner membrane

  1. AIFM1:​FAD@Mitochondrial inner membrane map

Participates in reactions:
As Reactant or Product:

  1. AIFM1@Mitochondrial inner membrane map map cleaved~AIFM1*@Mitochondrial intermembrane space map

  2. AIFM1@Mitochondrial inner membrane map + FAD@Mitochondrial inner membrane map map AIFM1:​FAD@Mitochondrial inner membrane map
  3. AIFM1@Mitochondrial inner membrane map + ROS@Mitochondrial inner membrane map map AIFM1|​don@Mitochondrial inner membrane map
  4. AIFM1|​don@Mitochondrial inner membrane map map cleaved~AIFM1*@Mitochondrial intermembrane space map
  5. AIFM1|​don@Mitochondrial inner membrane map map AIFM1@Mitochondrial inner membrane map

As Catalyser:

  1. degraded + NDUFS8@Mitochondrial inner membrane map + MT-ND5@Mitochondrial inner membrane map + MT-ND4@Mitochondrial inner membrane map + MT-ND4L@Mitochondrial inner membrane map + MT-ND3@Mitochondrial inner membrane map + MT-ND2@Mitochondrial inner membrane map + MT-ND1@Mitochondrial inner membrane map + MT-ND6@Mitochondrial inner membrane map map FMN:​MT-ND1:​MT-ND2:​MT-ND3:​MT-ND4:​MT-ND4L:​MT-ND5:​MT-ND6:​NDUFA1:​NDUFA10:​NDUFA11:​NDUFA12:​NDUFA13:​NDUFA2:​NDUFA3:​NDUFA4:​NDUFA5:​NDUFA6:​NDUFA7:​NDUFA8:​NDUFA9:​NDUFAB1:​NDUFB1:​NDUFB10:​NDUFB11:​NDUFB2:​NDUFB3:​NDUFB4:​NDUFB5:​NDUFB6:​NDUFB7:​NDUFB8:​NDUFB9:​NDUFC1:​NDUFC2:​NDUFS1|​[2Fe-2S],[4Fe-4S],[4Fe-4S]:​NDUFS2:​NDUFS3:​NDUFS4:​NDUFS5:​NDUFS6:​NDUFS7|​[4Fe-4S]:​NDUFS8|​[4Fe-4S],[4Fe-4S]:​NDUFV1|​[4Fe-4S]:​NDUFV2|​[2Fe-2S]:​NDUFV3@Mitochondrial inner membrane map

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