active~Caspases*

Protein active~Caspases* map

Identifiers
active BCR-related
HUGO:ABR HGNC:81 ENTREZ:29 UNIPROT:Q12979 GENECARDS:ABR REACTOME:405546 KEGG:29 ATLASONC:GC_ABR WIKI:ABR

Maps_Modules
 Apoptosis  map  / AKT_MTOR  map
 Apoptosis  map  / CASPASES  map
 Apoptosis  map  / MOMP_REGULATION  map

References
used to describe the effect of pan-caspase inhibitors such as z-VAD-fmk
Generic entity
NOTE:all caspases
CASP3
CASP6
CASP7
CASP8
CASP9

active~Caspases*@Cytoplasm

References
a_re709:( Apoptosis  map ) reactionType:is.a
a_re650( Apoptosis  map ):
in vitro by CASP3, CASP7, CASP8
in Ba/F3 upon IL3 deprivation, in FDCP1 upon IL3 deprivation, in U937 upon serum starvation, z-VAD-fmk inhibitable cleavage
a_re651( Apoptosis  map ):
in Ba/F3 upon doxorubicin or etoposide or anti-Fas
a_re708( Apoptosis  map ):
PMID:15665297
in Hela, cIAP1 is a nuclear protein, that partially translocates to the cytoplasm upon apoptotic stimuli (UV, staurosporin, TRAIL, TNF+CHX), and in a capase-dependent manner
a_re1004( Apoptosis  map ):
hierarchical:post-MOMP
reactionType:casp.cleavage
PMID:19171757
in C10 murine alveolar type II epithelial cells
a_re1152( Apoptosis  map ):
PMID:11399776
in vitro by CASP3 and to a lesser extent by CASP7
PMID:15073321
by LRDD and CRADD
a_re1242( Apoptosis  map ):
PMID:11287608
in 32D murine cells, upon IL3 withdrawal, BAD cleavage
in vitro cleavage of BAD by recombinant CASP 2,3,7,8,10, and GZMB
a_re1246( Apoptosis  map ):
influenceDelete: reactants to re
PMID:9435230
a_re1248:( Apoptosis  map ) PMID:7500007


Modifications:
In compartment: Cytoplasm
  1. active~Caspases*@Cytoplasm map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. cleaved~Caspase3*@Cytoplasm map map active~Caspases*@Cytoplasm map

    2. cleaved~Caspase7*@Cytoplasm map map active~Caspases*@Cytoplasm map
    3. cleaved~Caspase6*@Cytoplasm map map active~Caspases*@Cytoplasm map
    4. cleaved~Caspase9*@Cytoplasm map map active~Caspases*@Cytoplasm map
    5. cleaved~Caspase8*@Cytoplasm map map active~Caspases*@Cytoplasm map

    As Catalyser:

    1. GLRX@Cytoplasm map map cleaved~GLRX*@Cytoplasm map

    2. Caspase2*@Cytoplasm map map cleaved~Caspase2*@Cytoplasm map
    3. BAD|​unk@Cytoplasm map map cleaved~BAD*@Cytoplasm map
    4. BCL2-XL*@Mitochondrial outer membrane map map cleaved~BCL2_XL*@Mitochondrial outer membrane map
    5. DNA-PK*@Nucleus map map cleaved~DNA-PK*@Nucleus map
    6. PIK3C3@Cytoplasm map map cleaved~PIK3C3*@Cytoplasm map
    7. BECN1|​T119_unk@Cytoplasm map map cleaved~BECN1*@Cytoplasm map
    8. BIRC2@Nucleus map map BIRC2@Cytoplasm map

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