Actinin*

Protein Actinin* map

Identifiers
Actinin*
actinin, alpha 1
HUGO:ACTN1 HGNC:163 ENTREZ:87 UNIPROT:P12814 GENECARDS:ACTN1 REACTOME:49370 ATLASONC:GC_ACTN1 WIKI:ACTN1
actinin, alpha 2
HUGO:ACTN2 HGNC:164 ENTREZ:88 UNIPROT:P35609 GENECARDS:ACTN2 REACTOME:49372 KEGG:88 ATLASONC:GC_ACTN2 WIKI:ACTN2
actinin, alpha 4
“focal segmental glomerulosclerosis 1″, FSGS1
HUGO:ACTN4 HGNC:166 ENTREZ:81 UNIPROT:O43707 GENECARDS:ACTN4 REACTOME:49376 KEGG:81 ATLASONC:GC_ACTN4 WIKI:ACTN4

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CELL_MATRIX_ADHESIONS  map

References
PMID:15688067
Alpha-actinin is a cytoskeletal protein that binds to viculin (VCL).
Via this binding, Alpha-actinin crosslinks actin (in actomyosin stress fibres) and tether them to the focal contacts.
Phosphorylation of alpha-actinin by FAK1 (PTK2) reduces the crossliking of stress fibres and prevents the maturation of focal contacts.

Actinin*@Cytoplasm

References
e_re987( EMT  map ):
PMID:15688067
Alpha-actinin servers a link between cytoskeletal actin (in stress fibres) and vinculin at the focal contacts.
Phosphorylation of alpha-actinin by FAK1 (PTK2) redues this ability of linking actin to vinculin, thus prevents the maturation of focal contacts.
e_re991( EMT  map ):
Alpha-actinin is a cytoskeletal protein that binds to viculin (VCL).
Via this binding, Alpha-actinin crosslinks actin (in actomyosin stress fibres) and tether them to the focal contacts.
Phosphorylation of alpha-actinin by FAK1 (PTK2) reduces the crossliking of stress fibres and prevents the maturation of focal contacts.

Actinin*|​pho@Cytoplasm

References
e_re991( EMT  map ):
PMID:15688067
Alpha-actinin is a cytoskeletal protein that binds to viculin (VCL).
Via this binding, Alpha-actinin crosslinks actin (in actomyosin stress fibres) and tether them to the focal contacts.
Phosphorylation of alpha-actinin by FAK1 (PTK2) reduces the crossliking of stress fibres and prevents the maturation of focal contacts.


Modifications:
In compartment: Cytoplasm
  1. Actinin*@Cytoplasm map

  2. Actinin*|​pho@Cytoplasm map

Participates in complexes:
In compartment: Cytoplasm

  1. Actin cytoskeletal*:​Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​Vinculin*:​c-SRC*@Cytoplasm map

  2. Actin cytoskeletal*:​Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​Vinculin*:​ZYX:​c-SRC*@Cytoplasm map
  3. ARP2_3*:​Actin cytoskeletal*:​Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​Vinculin*:​c-SRC*@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. Actinin*@Cytoplasm map map ACTN1@Cytoplasm map

  2. Actinin*@Cytoplasm map map ACTN2@Cytoplasm map
  3. Actinin*@Cytoplasm map map ACTN4@Cytoplasm map
  4. BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​Vinculin*:​c-SRC*@Cytoplasm map + Actinin*@Cytoplasm map + Actin cytoskeletal*@Cytoplasm map map Actin cytoskeletal*:​Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​Vinculin*:​c-SRC*@Cytoplasm map
  5. Actin cytoskeletal*:​Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​Vinculin*:​c-SRC*@Cytoplasm map + ZYX@Cytoplasm map map Actin cytoskeletal*:​Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​Vinculin*:​ZYX:​c-SRC*@Cytoplasm map
  6. ARP2_3*@Cytoplasm map + Actin cytoskeletal*:​Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​Vinculin*:​c-SRC*@Cytoplasm map map ARP2_3*:​Actin cytoskeletal*:​Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​Vinculin*:​c-SRC*@Cytoplasm map
  7. ARP2_3*:​Actin cytoskeletal*:​Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​Vinculin*:​c-SRC*@Cytoplasm map map Actin polymerization@Nucleus map
  8. Actinin*@Cytoplasm map map Actinin*|​pho@Cytoplasm map

As Catalyser:

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