Actin polymerization

Phenotype Actin polymerization map
Actin polymerization@Nucleus

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CYTOSKELETON_POLARITY  map
 EMT  map  / CELL_CELL_ADHESIONS  map
 EMT  map  / CELL_MATRIX_ADHESIONS  map
 EMT  map  / ECM  map
 EMT  map  / TIGHT_JUNCTIONS  map
 EMT  map  / GAP_JUNCTIONS  map
 EMT  map  / ADHERENS_JUNCTIONS  map
 EMT  map  / DESMOSOMES  map

References
e_re715( EMT  map ):
PMID:9265657
ERM proteins can reconstitute stress fiber assembly, cortical actin polymerization and focal complex formation in response to activation of Rho and Rac
e_re799( EMT  map ):
CDC42 induces actin cytoskeleton changes by activating WASP and N-WASP.
WASP and N-WASP binds to ARP2/3 and this lieads to actin cytoskeletal polymerization and filopodia formation.
PMID:8625410
PMID:16293614
PMID:10467124
PMID:10511705
e_re852( EMT  map ):
CDC42 promotes changes in actin cytoskeleton by several pathways.
PMID:10461188
PMID:11950587
PMID:11340065
PMID:10559936
PMID:10613909
PMID:11413130
CDC42 activates PAK1,2,3,4 and CDC42BPA (MRCKalpha) which phosphorylate LIMK1,2.
LIMK1,2 subsquently phosphorylate and inhibit Cofilin
Destrin as actin depolymerizing factor, once phosphorylated by LIMK1,2 is inactive and thus this phosphorylation leads to actin polymerization and stimulation of filopodia and stress fibers formation.
e_re899( EMT  map ):
PMID:15866889
The ARP2_3 complex and Cofilin are involved in protrusion at the leading edge: the actin-severing activity of cofilin and the actin-branching activity of Arp2_3 act in synergy to drive the extension of lamellipodia.
Cofilin is also required for the maintenance of a polarized cytoskeleton and thus for directional cell migration.
Integrins control motile strategy through a Rho-cofilin pathway.
Adhesion to fibronectin by a5b1 integrin leads to phosphorylation and thus inactivation of cofilin.
Cells thus fail to polarize their cytoskeleton but extend thin protrusion with cell-matrix adhesions in multiple directions.


Modifications:
In compartment: Nucleus
  1. Actin polymerization@Nucleus map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. ERM*|​open@Cytoplasm map map Actin polymerization@Nucleus map

    2. GTP:​RHOA:​RhoA_cytoskeletal_effectors*@Cytoplasm map map Actin polymerization@Nucleus map
    3. GTP:​RHOB:​RhoB_cytoskeletal_effectors*@Cytoplasm map map Actin polymerization@Nucleus map
    4. Actin polymerization@Nucleus map map Cytoskeleton remodeling@Nucleus map
    5. ARP2_3*:​Actin cytoskeletal*@Cytoplasm map map Actin polymerization@Nucleus map
    6. Actin cytoskeletal*:​WASF2@Cytoplasm map map Actin polymerization@Nucleus map
    7. Actin cytoskeletal*:​DSTN@Cytoplasm map map Actin polymerization@Nucleus map
    8. Actin cytoskeletal*:​CFL1@Cytoplasm map map Actin polymerization@Nucleus map
    9. ARP2_3*:​Actin cytoskeletal*:​Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​Vinculin*:​c-SRC*@Cytoplasm map map Actin polymerization@Nucleus map
    10. s_s_wnc1_s1024 map Actin polymerization@Nucleus map

    As Catalyser:

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