Actin cytoskeletal*:WASF2

Complex Actin cytoskeletal*:WASF2 map


Complex composition:

  1. Actin cytoskeletal* map
  2. WASF2 map




Actin cytoskeletal*:​WASF2@Cytoplasm

Identifiers
NAME:Actin cytoskeletal*:WASF2

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CYTOSKELETON_POLARITY  map

References
e_re800( EMT  map ):
Rac1 binds to BAIAP2 which in turn associates with WASF2.
This stimulates ARP2/3 and leads to actin cytoskeleal polymerization.
PMID:16702231
WAVE2 (so-called WASF2) activates the ARP2/3 complex for Rac-induced actin polymerization during lamellipodium formation
PMID:9843499
WASF (WAVE) as regulator of actin reorganization downstream of Rac.
Expressed WAVE induces the formation of actin filament clusters.
WAVE plays a critical role downstream of Rac in regulating the actin cytoskeleton required for mem- brane ruffling
PMID:12054568
WAVE2 serves a functional partner of IRSp53 by regulating its interaction with Rac.

Confidence
REF=3 FUNC=4


Modifications:
Participates in complexes:
In compartment: Cytoplasm
  1. Actin cytoskeletal*:​WASF2@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. WASF2@Cytoplasm map + Actin cytoskeletal*@Cytoplasm map map Actin cytoskeletal*:​WASF2@Cytoplasm map

  2. Actin cytoskeletal*:​WASF2@Cytoplasm map map Actin polymerization@Nucleus map

As Catalyser:

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