e_re800( EMT ):
Rac1 binds to BAIAP2 which in turn associates with WASF2.
This stimulates ARP2/3 and leads to actin cytoskeleal polymerization.
WAVE2 (so-called WASF2) activates the ARP2/3 complex for Rac-induced actin polymerization during lamellipodium formation
WASF (WAVE) as regulator of actin reorganization downstream of Rac.
Expressed WAVE induces the formation of actin filament clusters.
WAVE plays a critical role downstream of Rac in regulating the actin cytoskeleton required for mem- brane ruffling
WAVE2 serves a functional partner of IRSp53 by regulating its interaction with Rac.
Participates in complexes:
In compartment: Cytoplasm
Participates in reactions:
As Reactant or Product:
- WASF2@Cytoplasm + Actin cytoskeletal*@Cytoplasm → Actin cytoskeletal*:WASF2@Cytoplasm
- Actin cytoskeletal*:WASF2@Cytoplasm → Actin polymerization@Nucleus