Actin cytoskeletal*:DSTN

Complex Actin cytoskeletal*:DSTN map


Complex composition:

  1. DSTN map
  2. Actin cytoskeletal* map




Actin cytoskeletal*:​DSTN@Cytoplasm

Identifiers
NAME:Actin cytoskeletal*:DSTN

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CYTOSKELETON_POLARITY  map

References
CDC42 promotes changes in actin cytoskeleton by several pathways.
PMID:10461188
PMID:11950587
PMID:11340065
PMID:10559936
PMID:10613909
PMID:11413130
CDC42 activates PAK1,2,3,4 and CDC42BPA (MRCKalpha) which phosphorylate LIMK1,2.
LIMK1,2 subsquently phosphorylate and inhibit Cofilin
Destrin as actin depolymerizing factor, once phosphorylated by LIMK1,2 is inactive and thus this phosphorylation leads to actin polymerization and stimulation of filopodia and stress fibers formation.

Confidence
REF=4 FUNC=4


Modifications:
Participates in complexes:
In compartment: Cytoplasm
  1. Actin cytoskeletal*:​DSTN@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. DSTN@Cytoplasm map + Actin cytoskeletal*@Cytoplasm map map Actin cytoskeletal*:​DSTN@Cytoplasm map

  2. Actin cytoskeletal*:​DSTN@Cytoplasm map map Actin polymerization@Nucleus map

As Catalyser:

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