Actin cytoskeletal*:CFL1

Complex Actin cytoskeletal*:CFL1 map


Complex composition:

  1. Actin cytoskeletal* map
  2. CFL1 map




Actin cytoskeletal*:​CFL1@Cytoplasm

Identifiers
NAME:Actin cytoskeletal*:CFL1

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CYTOSKELETON_POLARITY  map

References
PMID:10436159
ROCK phosphorylates LIMK1,2 which phosphorylates Cofilin (CFL1)
Cofilin exhibits actin depolymerizing activity followed by reorganization of the Actin cytoskeleton.
PMID:15866889
The ARP2_3 complex and Cofilin are involved in protrusion at the leading edge: the actin-severing activity of cofilin and the actin-branching activity of Arp2_3 act in synergy to drive the extension of lamellipodia.
Cofilin is also required for the maintenance of a polarized cytoskeleton and thus for directional cell migration.
e_re898( EMT  map ):
Integrins control motile strategy through a Rho-cofilin pathway.
Adhesion to fibronectin by a5b1 integrin leads to phosphorylation and thus inactivation of cofilin.
Cells thus fail to polarize their cytoskeleton but extend thin protrusion with cell-matrix adhesions in multiple directions.

Confidence
REF=2 FUNC=4


Modifications:
Participates in complexes:
In compartment: Cytoplasm
  1. Actin cytoskeletal*:​CFL1@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. CFL1@Cytoplasm map + Actin cytoskeletal*@Cytoplasm map map Actin cytoskeletal*:​CFL1@Cytoplasm map

  2. Actin cytoskeletal*:​CFL1@Cytoplasm map map Actin polymerization@Nucleus map

As Catalyser:

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