Actin cytoskeletal*

Protein Actin cytoskeletal* map

Identifiers
Actin cytoskeletal*
actin, alpha 1, skeletal muscle
ACTA
HUGO:ACTA1 HGNC:129 ENTREZ:58 UNIPROT:P68133 GENECARDS:ACTA1 REACTOME:49626 KEGG:58 ATLASONC:GC_ACTA1 WIKI:ACTA1
actin, alpha 2, smooth muscle, aorta
HUGO:ACTA2 HGNC:130 ENTREZ:59 UNIPROT:P62736 GENECARDS:ACTA2 REACTOME:49566 KEGG:59 ATLASONC:GC_ACTA2 WIKI:ACTA2
actin, beta
HUGO:ACTB HGNC:132 ENTREZ:60 UNIPROT:P60709 GENECARDS:ACTB REACTOME:49576 KEGG:60 ATLASONC:ACTBID42959ch7p22 WIKI:ACTB
actin, alpha, cardiac muscle 1
ACTC, “actin, alpha, cardiac muscle”
HUGO:ACTC1 HGNC:143 ENTREZ:70 UNIPROT:P68032 GENECARDS:ACTC1 REACTOME:49595 KEGG:70 ATLASONC:GC_ACTC1 WIKI:ACTC1
actin, gamma 1
ACTG, “deafness, autosomal dominant 20; deafness, autosomal dominant 26″, DFNA20, DFNA26
HUGO:ACTG1 HGNC:144 ENTREZ:71 UNIPROT:P63261 GENECARDS:ACTG1 REACTOME:49603 KEGG:71 ATLASONC:GC_ACTG1 WIKI:ACTG1
NEM3, “nemaline myopathy type 3″

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CYTOSKELETON_POLARITY  map
 EMT  map  / CELL_CELL_ADHESIONS  map
 EMT  map  / ADHERENS_JUNCTIONS  map
 EMT  map  / TIGHT_JUNCTIONS  map
 Survival  map  / WNT_NON_CANONICAL  map

Actin cytoskeletal*@Cytoplasm

References
e_re198( EMT  map ):
PMID:21900405
Integrin aVb6 activates the ECM-bound latent TGFB1 and TGFB3 by traction, without participation of MMPs, so no hydrolyse or clevage
Integrin aVb8 and MMP14 (so-called MT1-MMP) cooperate to activate the ECM-bound latent TGFB1 and TGFB3:
-Integrin aVb8 binds LAP from the large latent complex
-MMP14 then is recruited to cleave LAP
PMID:18342983
Two main models are proposed how integrins contribute to latent TGFB1 activation:
(1) In a protease-dependent mechanism, integrins avb8and avb3 are suggested to simultaneously bind the latent TGFB1 complex and proteinases.
This close vicinity at the cell surface improves enzymatic cleavage of the latent complex to release active TGFB1.
(2) Integrins avb3, avb5, avb6, and avb8 appear to change the conformation of the latent TGFB1 complex by transmitting cell traction forces.
PMID:19854168
Integrins are linked intracellularly to cytoskleletal elements and associated contractile machinery, and extracellularly to ECM.
Thus contractility of a cell bound to a rigid ECM generates force between a matrix molecule and its receptor. Such forces may uncouple LLCs so as to free TGFb.
PMID:16710477
The small GTPase RhoA has well established roles in contractility and has been shown to promote TGFb activation from LLCs.
e_re504( EMT  map ):
PMID:9334353
MLLT4 is so-called Afadin or AF-6
Afadin serves as a linker of the Actin cytoskeleton to the plasma membrane at the TJ sites
e_re798( EMT  map ):
Rac1 binds to BAIAP2 which in turn associates with WASF2.
This stimulates ARP2/3 and leads to actin cytoskeleal polymerization.
PMID:16702231
WAVE2 (so-called WASF2) activates the ARP2/3 complex for Rac-induced actin polymerization during lamellipodium formation
PMID:9843499
WASF (WAVE) as regulator of actin reorganization downstream of Rac.
Expressed WAVE induces the formation of actin filament clusters.
WAVE plays a critical role downstream of Rac in regulating the actin cytoskeleton required for mem- brane ruffling
PMID:12054568
WAVE2 serves a functional partner of IRSp53 by regulating its interaction with Rac.
PMID:15094799
ARP2_3 complex nucleates new actin filaments from the sides of preexisting filaments.
e_re851( EMT  map ):
CDC42 promotes changes in actin cytoskeleton by several pathways.
PMID:10461188
PMID:11950587
PMID:11340065
PMID:10559936
PMID:10613909
PMID:11413130
CDC42 activates PAK1,2,3,4 and CDC42BPA (MRCKalpha) which phosphorylate LIMK1,2.
LIMK1,2 subsquently phosphorylate and inhibit Cofilin
Destrin as actin depolymerizing factor, once phosphorylated by LIMK1,2 is inactive and thus this phosphorylation leads to actin polymerization and stimulation of filopodia and stress fibers formation.
e_re898( EMT  map ):
PMID:15866889
The ARP2_3 complex and Cofilin are involved in protrusion at the leading edge: the actin-severing activity of cofilin and the actin-branching activity of Arp2_3 act in synergy to drive the extension of lamellipodia.
Cofilin is also required for the maintenance of a polarized cytoskeleton and thus for directional cell migration.
Integrins control motile strategy through a Rho-cofilin pathway.
Adhesion to fibronectin by a5b1 integrin leads to phosphorylation and thus inactivation of cofilin.
Cells thus fail to polarize their cytoskeleton but extend thin protrusion with cell-matrix adhesions in multiple directions.
e_re987( EMT  map ):
PMID:15688067
Alpha-actinin servers a link between cytoskeletal actin (in stress fibres) and vinculin at the focal contacts.
Phosphorylation of alpha-actinin by FAK1 (PTK2) redues this ability of linking actin to vinculin, thus prevents the maturation of focal contacts.
e_re1025( EMT  map ):
PMID:16325583
Monomeric CTNNA1 binds more strongly to E-cadherin/CTNNB1, whereas the dimer preferentially binds actin filaments


Modifications:
In compartment: Cytoplasm
  1. Actin cytoskeletal*@Cytoplasm map

Participates in complexes:
In compartment: Cytoplasm

  1. Actin cytoskeletal*:​CFL1@Cytoplasm map

  2. Actin cytoskeletal*:​DSTN@Cytoplasm map
  3. Actin cytoskeletal*:​WASF2@Cytoplasm map
  4. Actin cytoskeletal*:​ZO1_2*@Cytoplasm map
  5. ARP2_3*:​Actin cytoskeletal*@Cytoplasm map
  6. Actin cytoskeletal*:​Afadin*@Cytoplasm map
  7. Actin cytoskeletal*:​Formin*@Cytoplasm map
  8. Actin cytoskeletal*:​Occludin*@Cytoplasm map
  9. Actin cytoskeletal*:​_alpha_-Catenin*|​hm2@Cytoplasm map
  10. Actin cytoskeletal*:​Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​Vinculin*:​c-SRC*@Cytoplasm map
  11. Actin cytoskeletal*:​Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​Vinculin*:​ZYX:​c-SRC*@Cytoplasm map
  12. ARP2_3*:​Actin cytoskeletal*:​Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​Vinculin*:​c-SRC*@Cytoplasm map

In compartment: Extracellular space

  1. Actin cytoskeletal*:​Integrin A8B1_AVB1_AVB5_AVB6_AVB8*:​LTBP1:​Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space map

Participates in reactions:
As Reactant or Product:

  1. Actin cytoskeletal*@Cytoplasm map + _alpha_-Catenin*|​hm2@Cytoplasm map map Actin cytoskeletal*:​_alpha_-Catenin*|​hm2@Cytoplasm map

  2. Formin*@Cytoplasm map + Actin cytoskeletal*@Cytoplasm map map Actin cytoskeletal*:​Formin*@Cytoplasm map
  3. Talin partners*@Cytoplasm map map Actin cytoskeletal*@Cytoplasm map
  4. Actin cytoskeletal*@Cytoplasm map + Integrin A8B1_AVB1_AVB5_AVB6_AVB8*:​LTBP1:​Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space map map Actin cytoskeletal*:​Integrin A8B1_AVB1_AVB5_AVB6_AVB8*:​LTBP1:​Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space map
  5. Actin cytoskeletal*:​Integrin A8B1_AVB1_AVB5_AVB6_AVB8*:​LTBP1:​Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space map map Integrin A8B1_AVB1_AVB5_AVB6_AVB8*:​LTBP1:​Latency-associated protein*|​hm2@Extracellular space map + TGFB1|​hm2|​active@Extracellular space map
  6. Actin cytoskeletal*@Cytoplasm map + Afadin*@Cytoplasm map map Actin cytoskeletal*:​Afadin*@Cytoplasm map
  7. Actin cytoskeletal*@Cytoplasm map + ZO1_2*@Cytoplasm map map Actin cytoskeletal*:​ZO1_2*@Cytoplasm map
  8. Occludin*@Cytoplasm map + Actin cytoskeletal*@Cytoplasm map map Actin cytoskeletal*:​Occludin*@Cytoplasm map
  9. Actin cytoskeletal*:​Occludin*@Cytoplasm map map Tight junctions@Extracellular space map
  10. Actin cytoskeletal*@Cytoplasm map map _alpha_1-Actin*@Cytoplasm map
  11. Actin cytoskeletal*@Cytoplasm map map _alpha_2-Actin*@Cytoplasm map
  12. Actin cytoskeletal*@Cytoplasm map map _beta_-Actin*@Cytoplasm map
  13. Actin cytoskeletal*@Cytoplasm map map _alpha_-Actin*@Cytoplasm map
  14. Actin cytoskeletal*@Cytoplasm map map _gamma_-Actin*@Cytoplasm map
  15. Actin cytoskeletal*@Cytoplasm map + ARP2_3*@Cytoplasm map map ARP2_3*:​Actin cytoskeletal*@Cytoplasm map
  16. ARP2_3*:​Actin cytoskeletal*@Cytoplasm map map Actin polymerization@Nucleus map
  17. WASF2@Cytoplasm map + Actin cytoskeletal*@Cytoplasm map map Actin cytoskeletal*:​WASF2@Cytoplasm map
  18. Actin cytoskeletal*:​WASF2@Cytoplasm map map Actin polymerization@Nucleus map
  19. DSTN@Cytoplasm map + Actin cytoskeletal*@Cytoplasm map map Actin cytoskeletal*:​DSTN@Cytoplasm map
  20. Actin cytoskeletal*:​DSTN@Cytoplasm map map Actin polymerization@Nucleus map
  21. ARP2_3*:​Actin cytoskeletal*@Cytoplasm map map Filopodium formation@Nucleus map
  22. CFL1@Cytoplasm map + Actin cytoskeletal*@Cytoplasm map map Actin cytoskeletal*:​CFL1@Cytoplasm map
  23. Actin cytoskeletal*:​CFL1@Cytoplasm map map Actin polymerization@Nucleus map
  24. BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​Vinculin*:​c-SRC*@Cytoplasm map + Actinin*@Cytoplasm map + Actin cytoskeletal*@Cytoplasm map map Actin cytoskeletal*:​Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​Vinculin*:​c-SRC*@Cytoplasm map
  25. Actin cytoskeletal*:​Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​Vinculin*:​c-SRC*@Cytoplasm map + ZYX@Cytoplasm map map Actin cytoskeletal*:​Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​Vinculin*:​ZYX:​c-SRC*@Cytoplasm map
  26. ARP2_3*@Cytoplasm map + Actin cytoskeletal*:​Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​Vinculin*:​c-SRC*@Cytoplasm map map ARP2_3*:​Actin cytoskeletal*:​Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​Vinculin*:​c-SRC*@Cytoplasm map
  27. ARP2_3*:​Actin cytoskeletal*:​Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​Vinculin*:​c-SRC*@Cytoplasm map map Actin polymerization@Nucleus map
  28. APC@Cytoplasm map + HTID1_50_48_kDa_isoform*@Cytoplasm map + HSP70*@Cytoplasm map + DVL*@Cytoplasm map + Actin cytoskeletal*@Cytoplasm map + AXIN*@Cytoplasm map + HSC70*@Cytoplasm map map AXIN*:​DVL*:​HSC70*:​HTID1_50_48_kDa_isoform*@Cytoplasm map

As Catalyser:

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