ACLY

Protein ACLY map

Identifiers
ATP citrate lyase
HUGO:ACLY HGNC:115 ENTREZ:47 UNIPROT:P53396 GENECARDS:ACLY REACTOME:49538 KEGG:47 ATLASONC:ACLYID50486ch17q21 WIKI:ACLY

Maps_Modules
 Apoptosis  map  / MITOCH_METABOLISM  map

ACLY@Cytoplasm

References
a_re301( Apoptosis  map ):
PMID:10653665
in vitro, S454 phosphorylation of ACLY increases its activity
PMID:12107176
in primary rat adipocytes, Akt mediated ACLY S454 phosphorylation
a_re303( Apoptosis  map ):
fructose 6-phosphate was found to be a potent activator (60-fold) of the unphosphorylated recombinant enzyme

ACLY|​S454_pho@Cytoplasm

References
a_re301( Apoptosis  map ):
PMID:10653665
in vitro, S454 phosphorylation of ACLY increases its activity
PMID:12107176
in primary rat adipocytes, Akt mediated ACLY S454 phosphorylation
a_re302:( Apoptosis  map ) reactionType:is.a

ACLY|​S454_don|​hm4@Cytoplasm

References
a_re302:( Apoptosis  map ) reactionType:is.a
a_re303( Apoptosis  map ):
PMID:10653665
fructose 6-phosphate was found to be a potent activator (60-fold) of the unphosphorylated recombinant enzyme


Modifications:
In compartment: Cytoplasm
  1. ACLY@Cytoplasm map

  2. ACLY|​S454_pho@Cytoplasm map
  3. ACLY|​S454_don|​hm4@Cytoplasm map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. ACLY@Cytoplasm map + ATP@Cytoplasm map map ACLY|​S454_pho@Cytoplasm map + ADP@Cytoplasm map

    2. ACLY|​S454_pho@Cytoplasm map map ACLY|​S454_don|​hm4@Cytoplasm map
    3. ACLY@Cytoplasm map + fructose-6P@Cytoplasm map map ACLY|​S454_don|​hm4@Cytoplasm map

    As Catalyser:

    1. citrate@Cytoplasm map + ATP@Cytoplasm map + coenzyme A@Cytoplasm map map acetyl-CoA@Cytoplasm map + oxaloacetate@Cytoplasm map + ADP@Cytoplasm map

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