a_re633

Reaction state_transition a_re633 map

BAD|​pho@Cytoplasm map BAD@Cytoplasm map

Reaction regulators:

Catalysis
  1. Ca2+:​PPP3CB:​PPP3R1@Cytoplasm map



References
logical:re633_s3146_re638=FALSE
PMID:10195903
in 293T cells or 293T cells expressing constitutively active Akt, upon over-expression of constitutive active calcineurin (DeltaCnA/CnB)
in HCT116 colon cancer cells, Ca2+ increase (thapsigargin, ionomycin) inhibits BAD S75 phosphorylation and interaction of BAD with 14-3-3 or PP3CB.
in transfected 293T, co-IP BAD phosphomimetic mutant with PPP3CB
in Du145 prostate cancer cells, Ca2+ induced dephosphorylation of BAD correlates with its relocalization to mitochondria
in CSM14.1 immortalized rat hippocampal cells, exogenously expressed BAD-GFP relocalizes to mitochondria in response to cytoplasmic Ca2+ increased (THG, A23187)
in primaryin primary rat hippocampal neurons, L-glutamate induces cell death and relocalization to mitochondria of BAD-GFP, which are both inhibited by co-expression of dominant negative DeltaCnA(H101Q)
in 293T cells or 293T cells expressing mitochondria-targeted RAF1, upon over-expression of constitutive active calcineurin (DeltaCnA/CnB)

Confidence
REF=1 FUNC=4


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