a_re506

Reaction state_transition a_re506 map

Caspase9*|​S196_unk|​T125_unk|​S144_unk|​Y153_unk@Cytoplasm map → degraded

Reaction regulators:

Catalysis
  1. CAPN2:​Ca2+_@Cytoplasm map



References
PMID:10671558
in vitro with recombinant proteins
cleavage of recombinant CASP9 by cellular extract, in a Ca2+ dose-dependent manner
in Hela cell extracts, preincubation with Ca2+ and CAPN2 prevents Cyt_c-mediated CASP3 cleavage
in SH-SY5Y human neuroblastoma cells Ca2+ ionophore (A23187) treatment
CAPN2-cleaved CASP9 is inactive
CASP78 are also cleaved by CAPN2, but the effect on their activity is unknown

Confidence
REF=1 FUNC=5


Leave a Reply