Reaction state_transition a_re484

Caspase9*@Cytoplasm → cleaved~Caspase9*@Cytoplasm

Reaction regulators:

Catalysis

1. (d)ATP:​APAF1:​Cytochrome_C*|​ferroheme@Cytoplasm
2. NOD1@Cytoplasm

Unknown_inhibition

1. BIRC5|​T34_pho:​HBXIP@Cytoplasm

References
PMID:15210107
reviews the differerent hypothesis concerning the biochemical events leading to activation of CASP9
PMID:12773388
in vitro, survivin and HBXIP together inhibits CASP9 processing and activation
in HT1080 cells, coexpression of BIRC5 and HBXIP suppresses staurosporin-induced apoptosis
in cell extracts from Hela transfected with siRNA against HBXIP, CYCS induced caspase activation is suppressed
PMID:10329646
by NOD1

Confidence
REF=2 FUNC=4