a_re482

Reaction state_transition a_re482 map

Cytochrome_C*|​ferroheme@Cytoplasm map + (d)ATP@Cytoplasm map + APAF1@Cytoplasm map (d)ATP:​APAF1:​Cytochrome_C*|​ferroheme@Cytoplasm map

Reaction regulators:

Boolean_logic_gate_and
  1. ANP32A@Cytoplasm map and CSE1L@Cytoplasm map and HSP70*@Cytoplasm map
Catalysis
  1. HSP70*@Cytoplasm map
  2. AFP@Cytoplasm map
  3. ANP32A@Cytoplasm map
  4. CSE1L@Cytoplasm map
Inhibition
  1. PTMA@Cytoplasm map
Unknown_catalysis
  1. ACHE@Cytoplasm map



References
PMID:17377525
review on apoptosome formation
PMID:11864614
stoechiometry apoptosome
PMID:12522243
inhibition of apoptosome formation by prothymosin-alpha
PMID:15087373
in HT-29 colon adenocarcinoma cells, siRNA against ACHE prevents the APAF1:CYCS interaction and etoposide-induced
PMID:14622304
AFP positive influence on apoptosome assembly
PMID:18439902
CAS PHAPI and HSP70 enhance apoptosome formation and caspase activation

Confidence
REF=5 FUNC=3


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