a_re442

Reaction state_transition a_re442 map

BimEL*@Cytoplasm map BimEL*|​S87_pho@Cytoplasm map

Reaction regulators:

Catalysis
  1. AKT*|​S473_pho|​T308_pho@Cytoplasm map



References
PMID:16282323
in murine BA/F3 IL3-dependent cells, multisite phosphorylation of BimEL upon IL3. Attenuated by ERK and PI3K inhibitors.
in vitro, active mouse Akt purified from IL3 treated BAF3 cells phosphorylates recombinant human BimEL. Blocked by mutation of S87

Confidence
REF=1 FUNC=4


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