a_re436

Reaction state_transition a_re436 map

BimEL*@Cytoplasm map BimEL*|​S69_pho@Cytoplasm map

Reaction regulators:

Catalysis
  1. ERK*@Cytoplasm map



References
PMID:12646560
in CCL39 chinese hamster lung fibroblast cell line
PMID:15486085
in IL-3 dependent mouse pro-B cell line FL5.12, upon IL-3, ERK dependent phosphorylation of BimEL on S55, S65, S100 (mouse Bim)
in vitro, ERK2 phosphorylates mouse BimEL
in mouse BAF3 cells, in TF-1 human granulocyte macrophage- colony stimulating factor-dependent er ythroleukemia cell line, and in mouse embr yonic fibroblasts when IGF-1 was used as a survival factor, an upshift in BimEL (not BimL) electrophoretic mobility upon IL3. This upshift is lost in FL5.12 if phosphosites are mutated.
PMID:19150432

Confidence
REF=3 FUNC=3


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