a_re387

Reaction state_transition a_re387 map

HIF1A@Cytoplasm map + O_sub_2_endsub_@Cytoplasm map + 2-oxoglutarate@Cytoplasm map HIF1A|​P564_hyd@Cytoplasm map + succinate@Cytoplasm map + CO_sub_2_endsub_@Cytoplasm map

Reaction regulators:

Boolean_logic_gate_and
  1. Fe2+:​PHD*@Cytoplasm map and OS9@Cytoplasm map
Catalysis
  1. OS9@Cytoplasm map
  2. Fe2+:​PHD*@Cytoplasm map
Inhibition
  1. succinate@Cytoplasm map
  2. fumarate@Cytoplasm map



References
PMID:12351678
identification of PHD2 as a HIF1A prolyl hydroxylase
PMID:15652751
inhibition of HIF1A prolyl hydroxylation by succinate and fumarate
PMID:15721254
in 293 cells, OS9 interacts with HIF1 and PHD and promotes HIF1A prolylhydroxylation and degradation

Confidence
REF=3 FUNC=5


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