a_re386

Reaction state_transition a_re386 map

HIF1A|​P564_hyd@Cytoplasm map HIF1A|​ubi|​P564_hyd@Cytoplasm map

Reaction regulators:

Catalysis
  1. CUL2:​RACK1*:​RBX1:​TCEB1:​TCEB2:​VHL@Cytoplasm map
Inhibition
  1. STAT3|​S727_pho@Cytoplasm map
  2. HSP90*@Cytoplasm map



References
PMID:10973499
in vitro reconstitution of the E3-ligase activity, with VHL, elonginB/C, RBX1,CUL2
PMID:18985005
in COS monkey kidney cells and Caki-I human renal carcinoma cells, inhibition of VHL-mediated HIF1A ubiquitinylation and degradation by ectopically expressed constitutively active STAT3

Confidence
REF=2 FUNC=4


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