a_re375

Reaction state_transition a_re375 map

degraded → Autophagy@Cytoplasm map

Reaction regulators:

Boolean_logic_gate_and
  1. BECN1|​T119_unk@Cytoplasm map and PIK3C3@Cytoplasm map and DRAM1@Cytoplasm map
Catalysis
  1. PIK3C3@Cytoplasm map
  2. BECN1|​T119_unk@Cytoplasm map
  3. DRAM1@Cytoplasm map
Inhibition
  1. MLST8:​MTOR:​RPTOR|​unk@Cytoplasm map
Unknown_catalysis
  1. NH3@Cytoplasm map



References
PMID:15146184
inhibition relieved in mouse model of Huntington disease, where mTOR is inhibited by sequestration into polyglutamine aggregates
PMID:16839881
p53 target gene DRAM1 is necessary for induction of autophagy
PMID:20424262
by ammonia

Confidence
REF=3 FUNC=3


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