a_re1494

Reaction state_transition a_re1494 map

H2AFX|​Y142_pho@Nucleus map H2AFX|​S139_pho|​Y142_pho@Nucleus map

Reaction regulators:

Boolean_logic_gate_and
  1. JNK*|​Y185_pho|​T183_pho@Nucleus map and APBB1@Nucleus map
Catalysis
  1. JNK*|​Y185_pho|​T183_pho@Nucleus map
  2. APBB1@Nucleus map



References
PMID:16818236
upon UVA irradiation (no DSB), phosphorylation of H2AX S139 by JNK
effect of Y142 phosphorylation not assessed
PMID:19234442
interaction between JNK1 and H2AX Y142_pho dependent on FE65 (proposed FE65 scaffolding JNK to Y142_pho)
they propose H2AX Y142 phosphorylation as a switch toward apoptosis.
Even if not fully documented, the information from these 2 papers is merged into this representation where doubly phosphorylated H2AX cooperated with CAD for DNA fragmentation

Confidence
REF=2 FUNC=4


Leave a Reply