a_re146

Reaction transcription a_re146 map

gMIR17-92*@Nucleus map arMIR17-92*@Nucleus map

Reaction regulators:

Catalysis
  1. E2F1@Nucleus map
  2. MYC@Nucleus map
Inhibition
  1. p53*|​S15_pho|​active@Nucleus map



References
PMID:18328430
MIR17HG transactivation by E2F1
PMID:15944709
MIR17-92 cluster transactivation by MYC
PMID:19696742
MIR17HG transactivation repressed by TP53. Proposed mechanism: TP53- and TBP- binding sites overlaps.
in human colorectal carcinoma HCT116 (TP53 competent cells), MIR17HG repression upon hypoxia and TP53 stabilization.
in human colorectal carcinoma cells HCT116 and LOVO, this effect is blocked by siRNA against TP53
in HCT116 and LOVO, siRNA against MYC represses MIR17-92 expression

Confidence
REF=3 FUNC=4


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