a_re1420

Reaction dissociation a_re1420 map

BAD|​S91_unk:​BCL2@Mitochondrial outer membrane map BCL2@Mitochondrial outer membrane map + BAD|​pho@Cytoplasm map

Reaction regulators:

Catalysis
  1. RAF1@Cytoplasm map



References
PMID:8929532
in vitro RAF1:BCL2 interaction
in 293, overexpression of BCL2 induces relocalization of RAF1-GFP to mitochondria
in vitro phosphorylation of BAD by RAF1
in 293T, over-expression of a mitochondria-targeted version of RAF1 induces phosphorylation of BAD (controls: plasma membrane targeted RAF1, kinase dead mutant)
BCL2 over-expression targets RAF1 kinase domain-GFP to mitochondria
mitochondria-targeted RAF1 (deleted for Ras binding domain) potentiates BCL2 anti-apoptotic activity in 32D.3 exposed to staurosporine or upon IL-3 withdrawal

Confidence
REF=1 FUNC=5


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