a_re1409

Reaction state_transition a_re1409 map

BCL2@Mitochondrial outer membrane map BCL2|​pho@Mitochondrial outer membrane map

Reaction regulators:

Catalysis
  1. JNK*|​Y185_pho|​T183_pho@Cytoplasm map
  2. ERK*@Cytoplasm map
  3. PRKCA@Cytoplasm map



References
PMID:9115213
S70 phosphorylation of BCL2 necessary for its antiapoptotic function
in NSF/N1.H7 mouse leukemia cells BCL2 mutants transfection) in response to IL-3, etoposide, or bryostatin-1, a PKC activator
PMID:9738012
suggest that PRKCA is the main PRKC BCL2 kinase in HL60 human acute myeloid leukemia cell line
PMID:10677502
ERK1/2 is a BCL2 S70 kinase in NSF/N1.H7 cells stimulated with IL-3
in vitro direct phosphorylation
PMID:11323415
JNK is a BCL2 S70 kinase in NSF/N1.H7 cells upon IL-3 withdrawal

Confidence
REF=4 FUNC=4


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