a_re1200

Reaction translation a_re1200 map

rHIF1B*@Nucleus map HIF1B*@Nucleus map

Reaction regulators:

Inhibition
  1. arMIR107@Cytoplasm map



References
PMID:20308559
bioinformatic prediction
in HCT116, expression of MIR107 precursor decreases ARNT protein abundance
in HCT116, in Hela, in SW480, RNA antisens to MIR107 increases ARNT protein abundance
+ luciferase reporter assay using the 3′UTR of ARNT
in HCT116, knockdown of endogenous miR-107 increased desferrioxamine(hypoxia mimick)-induced VEGF levels, which is rescued by a expression of ARNT lacking its 3′UTR.
in HCT116, pre-miR-107 decreases the ability of HCT116 cells to stimulate endothelial proliferation upon hypoxia (MMT assay)

Confidence
REF=1 FUNC=0


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